Department of Geriatrics, Hanoi Hospital of Traditional Medicine, Hanoi, Vietnam.
Inventive Medical Foundation, Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, U.S.A.
In Vivo. 2024 Mar-Apr;38(2):963-970. doi: 10.21873/invivo.13528.
BACKGROUND/AIM: Knee osteoarthritis (KOA) is the most common disease in adults. We conducted a clinical study to evaluate the efficacy and safety of Bach Nien Kien (BNK) in supportive therapy for patients with symptomatic KOA.
An open interventional study was performed on 60 patients aged 38 to 70 with the diagnosis of symptomatic KOA. The patients were assigned to a study group (SG) with 30 subjects and a control group (CG) with 30 subjects using a matching method. The patients in SG were treated with electroacupuncture, glucosamine supplement, and BNK, while the patients in CG received the same treatment without BNK.
At the end of the 30-day treatment (d30), the SG had a reduction in VAS score compared to a pre-treatment level of 3.03±0.96 points, which was more than the CG of 2.5±0.90 points. The excellent result in the SG was 10%, and the CG had no excellent result. The good result in the SG was 56.7%, and the CG group was only 26.7%. The moderate and poor results in the CG were high, 63.3%, and 10%, respectively; in the SG, only 26.7% and 6.7%. The difference in overall treatment results between the SG and CG was statistically significant (p<0.05). During the 30-day treatment period in both groups, no patient reported any undesirable effects.
Bach Nien Kien health supplement is effective and safe for controlling KOA symptoms and improving joint motion and quality of life for patients with symptomatic KOA.
背景/目的:膝骨关节炎(KOA)是成年人中最常见的疾病。我们进行了一项临床研究,以评估 Bach Nien Kien(BNK)在治疗有症状的 KOA 患者中的疗效和安全性。
对 60 名年龄在 38 至 70 岁之间的有症状的 KOA 患者进行了一项开放的干预性研究。使用匹配方法将患者分为研究组(SG)和对照组(CG),每组 30 例。SG 患者接受电针、氨基葡萄糖补充剂和 BNK 治疗,而 CG 患者接受相同的治疗但不使用 BNK。
在 30 天治疗结束时(d30),SG 的 VAS 评分与治疗前的 3.03±0.96 分相比降低了 3.03±0.96 分,而 CG 为 2.5±0.90 分。SG 的优秀结果为 10%,CG 无优秀结果。SG 的良好结果为 56.7%,CG 组仅为 26.7%。CG 组中度和差的结果较高,分别为 63.3%和 10%;而 SG 组仅为 26.7%和 6.7%。SG 和 CG 之间的总体治疗结果差异具有统计学意义(p<0.05)。在两组的 30 天治疗期间,没有患者报告任何不良反应。
Bach Nien Kien 健康补充剂对于控制 KOA 症状、改善关节运动和提高有症状的 KOA 患者的生活质量是有效和安全的。