Pancreas Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, People's Republic of China; Pancreas Institute, Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China.
Pancreas Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, People's Republic of China; Pancreas Institute, Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China.
Cytokine. 2019 Mar;115:50-59. doi: 10.1016/j.cyto.2018.12.003. Epub 2019 Jan 8.
Single nucleotide polymorphisms (SNPs) within the interleukins (IL) gene may affect the risk of acute pancreatitis. Many epidemiological studies have reported an association between the IL gene and acute pancreatitis risk, but the results remain inconsistent. Given the controversial available data, we carried out a meta-analysis to systematically evaluate and clarify the association between IL gene polymorphisms and AP. A systematic search of studies for this association was obtained from the PubMed, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) databases until June 1, 2017. We also searched the references of the included studies to identify additional studies. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to pool the effect size. Stata12.0 was used for whole statistical analysis. Fifteen studies that contained 3371 AP cases and 3506 controls were included in final combination. Overall, a significant association was found between the IL-8-251 T/A (rs4073) polymorphism, the IL-10-1082 A/G (rs1800896) polymorphism and the AP risk in four genetic models (homozygote model, recessive model, dominant model, allele model). Meanwhile, individuals with IL-1β+3954 C/T (rs1143634, (homozygote model, recessive model)), IL-1β -511 C/T (rs16944, (dominant model)) and IL-6-634C/G (rs1800796, (allele model)) polymorphism were associated with an increased risk of AP. No evidence of an association was found between IL and 10-592 C/A (rs1800872) and IL-10-819 C/T (rs1800871) polymorphism and AP risk.
单核苷酸多态性（SNPs）在白细胞介素（IL）基因中可能会影响急性胰腺炎的风险。许多流行病学研究报告了白细胞介素基因与急性胰腺炎风险之间的关联，但结果仍不一致。鉴于现有数据存在争议，我们进行了荟萃分析，以系统评估和阐明白细胞介素基因多态性与急性胰腺炎的关系。从 PubMed、EMBASE、Web of Science 和中国国家知识基础设施（CNKI）数据库中系统地检索了与该关联相关的研究，并于 2017 年 6 月 1 日之前进行了搜索。我们还检索了纳入研究的参考文献，以确定其他研究。使用 95%置信区间（95%CI）的优势比（ORs）来汇总效应大小。使用 Stata12.0 进行了所有统计分析。最终组合纳入了 15 项研究，包含 3371 例急性胰腺炎病例和 3506 例对照。总体而言，在四种遗传模型（纯合子模型、隐性模型、显性模型、等位基因模型）中发现白细胞介素-8-251 T/A（rs4073）多态性、白细胞介素-10-1082 A/G（rs1800896）多态性与急性胰腺炎风险之间存在显著关联。同时，白细胞介素 1β+3954 C/T（rs1143634，纯合子模型、隐性模型）、白细胞介素 1β-511 C/T（rs16944，显性模型）和白细胞介素 6-634C/G（rs1800796，等位基因模型）多态性与急性胰腺炎风险增加相关。白细胞介素 10-592 C/A（rs1800872）和白细胞介素 10-819 C/T（rs1800871）多态性与急性胰腺炎风险之间无关联证据。
