白细胞介素-10基因rs1800896多态性增加急性胰腺炎风险。
Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis.
作者信息
Zhou Hongmei, Liu Ailing, Zhou Bingzhi, Zhao Cunxin, Jin Guangjun
机构信息
Department of Gastroenterology Department of Emergency, Yi Du Central Hospital of Wei Fang, Shandong Department of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
出版信息
Medicine (Baltimore). 2017 Dec;96(48):e9006. doi: 10.1097/MD.0000000000009006.
BACKGROUND
The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.
METHODS
Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was assessed using pooled odds ratios and 95% confidence intervals.
RESULTS
Totally 7 case-control studies involving 1527 cases and 1511 controls were identified. Analyses proved that IL-10 gene rs1800896 polymorphism was significantly associated with an increased risk of AP. Stratification analysis of ethnicity found such significant association only among Asians, but not Caucasians.
CONCLUSION
IL-10 gene rs1800896 polymorphism increases the risk of AP.
背景
多项研究探讨了白细胞介素-10（IL-10）基因rs1800896多态性与急性胰腺炎（AP）易感性之间的关联，但结果相互矛盾。因此，需要进行一项全面的荟萃分析来评估这种关联的强度。
方法
检索PubMed、EMBASE和中国知网（CNKI）上的文献以识别相关研究。使用合并比值比和95%置信区间评估IL-10基因rs1800896多态性与AP风险之间的关联强度。
结果
共纳入7项病例对照研究，涉及1527例病例和1511例对照。分析表明，IL-10基因rs1800896多态性与AP风险增加显著相关。种族分层分析发现，这种显著关联仅在亚洲人中存在，在白种人中不存在。
结论
IL-10基因rs1800896多态性增加了AP的风险。
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