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白细胞介素-8 rs4073 多态性与急性胰腺炎的弱关联性：累积荟萃分析。

Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis.

机构信息

Cardiovascular Institute of Luohe and Departments of Intense Care Unit (YL), Endocrinology (JB), Arthritis Surgery (BH), Pediatrics (NW) and Cardiology (HW and DL), Luohe Central Hospital, Luohe Medical College, 56# Renmin Ave, Luohe, 462000, People's Republic of China.

出版信息

BMC Med Genet. 2019 Jul 24;20(1):129. doi: 10.1186/s12881-019-0861-4.

DOI:10.1186/s12881-019-0861-4
PMID:31340771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6657145/
Abstract

BACKGROUND

Several studies have been performed to investigate the associations between interleukin (IL)-8 rs4073 polymorphism and acute pancreatitis (AP), but the results are inconclusive. We conducted this cumulative meta-analysis for a precise estimate of the relationship between IL-8 rs4073 polymorphism and acute pancreatitis.

METHODS

We searched the electronic databases for relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. For a better presentation of how the pooled ORs changed as updated evidence accumulated, we used forest plots from a cumulative meta-analysis method.

RESULTS

Ten studies involving 1646 AP patients and 1816 controls were finally included in this meta-analysis. Cumulative meta-analyses indicated there is a consistent trend toward association after the initial discovery. Under the allelic, dominant, recessive and homozygous models, the pooled ORs were 1.265 (1.147-1.395, p < 0.001), 1.304 (1.127-1.508, p < 0.001), 1.431 (1.203-1.702, p < 0.001), and 1.634 (1.334-2.001, p < 0.001), respectively.

CONCLUSIONS

This meta-analysis demonstrated a suggestive result that people who carried the risk A allele of the IL-8 rs4073 polymorphism may be more sensitive to acute pancreatitis.

摘要

背景

已有多项研究探讨了白细胞介素（IL）-8 rs4073 多态性与急性胰腺炎（AP）之间的关联，但结果尚无定论。我们进行了这项累积荟萃分析，以更准确地评估 IL-8 rs4073 多态性与急性胰腺炎之间的关系。

方法

我们检索了电子数据库中的相关研究。使用优势比（OR）和 95%置信区间（CI）来评估关联的强度。为了更好地展示随着新证据的积累，汇总 OR 如何变化，我们使用了累积荟萃分析方法的森林图。

结果

最终纳入了这项荟萃分析的 10 项研究，共包括 1646 例 AP 患者和 1816 例对照。累积荟萃分析表明，在初始发现后存在一致的关联趋势。在等位基因、显性、隐性和纯合子模型下，汇总 OR 分别为 1.265（1.147-1.395，p<0.001）、1.304（1.127-1.508，p<0.001）、1.431（1.203-1.702，p<0.001）和 1.634（1.334-2.001，p<0.001）。

结论

这项荟萃分析表明，携带白细胞介素-8 rs4073 多态性风险 A 等位基因的人可能对急性胰腺炎更敏感，这是一个有提示意义的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/20b3057687d4/12881_2019_861_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/f6418bae4f91/12881_2019_861_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/b2cdbc93f781/12881_2019_861_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/41e0ee80a8db/12881_2019_861_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/ab8dc27be77d/12881_2019_861_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/20b3057687d4/12881_2019_861_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/f6418bae4f91/12881_2019_861_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/b2cdbc93f781/12881_2019_861_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/41e0ee80a8db/12881_2019_861_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/ab8dc27be77d/12881_2019_861_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19af/6657145/20b3057687d4/12881_2019_861_Fig5_HTML.jpg

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