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冷场水果提取物在体外具有不同的抗氧化和抗增殖活性。

Cold-field fruit extracts exert different antioxidant and antiproliferative activities in vitro.

作者信息

Fan Zi-Luan, Wang Zhen-Yu, Liu Jia-Ren

机构信息

Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China.

Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China; Northeast Forestry University, 26 Hexing Road, Xiangfang District, Harbin 150040, PR China.

出版信息

Food Chem. 2011 Nov 15;129(2):402-407. doi: 10.1016/j.foodchem.2011.04.091. Epub 2011 May 4.

DOI:10.1016/j.foodchem.2011.04.091
PMID:30634244
Abstract

Consumption of plant phenolics in the daily diet has been recognised as lowering the risk of aging-associated diseases. A total of 11 cold-field fruits in China were evaluated for total contents of phenolics, flavonoids and anthocyanins, and antioxidant and antiproliferation activities. Total phenolic contents of the fruits extracts had a positive correlation with antioxidant activity (R>0.7112). Among the 11 fruits, the extracts of raspberry had the highest capacities for scavenging DPPH (EC 25.6±0.51μM TE/g FW) and ABTS (EC 63.6±1.67μM TE/g FW). Proliferation of HepG2 and HT-29 cells was significantly inhibited in a dose-dependent pattern after exposure to the fruit extracts, among which lingonberry and rowanberry exhibited the highest antiproliferative activities. These results provide new knowledge on health functions of fruits and the fruits with high antioxidant contents are recommended for potential health benefits.

摘要

日常饮食中摄入植物酚类物质已被认为可降低与衰老相关疾病的风险。对中国11种寒地水果的酚类、黄酮类和花青素总含量以及抗氧化和抗增殖活性进行了评估。水果提取物的总酚含量与抗氧化活性呈正相关（R>0.7112）。在这11种水果中，树莓提取物清除DPPH（EC 25.6±0.51μM TE/g FW）和ABTS（EC 63.6±1.67μM TE/g FW）的能力最强。HepG2和HT-29细胞在接触水果提取物后，其增殖受到显著抑制，且呈剂量依赖性，其中越橘和花楸的抗增殖活性最高。这些结果为水果的健康功能提供了新知识，建议食用具有高抗氧化成分的水果以获取潜在的健康益处。

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