Pärnänen Pirjo, Niikko Sari, Lähteenmäki Hanna, Räisänen Ismo T, Tervahartiala Taina, Sorsa Timo, Ranki Annamari
Department of Oral and Maxillofacial Diseases, Head and Neck Center, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
Dental Clinic Miun Paikka, 80100 Joensuu, Finland.
Microorganisms. 2024 Sep 6;12(9):1850. doi: 10.3390/microorganisms12091850.
This review is focused on the effects of lingonberry ( L.) fruit phenolic compounds in human in vitro cells and in vivo clinical studies. Studies with lingonberries, lingonberry juice/lingonberry nectar/fermented lingonberry juice, and phenolic fractions with active molecules are reviewed. Lingonberry's bioactive substances have a diverse range of antimicrobial, anti-inflammatory, antiproteolytic, anticancer, and antioxidant properties. Fermentation of lingonberries and modulation of the dysbiotic microbiome to a more symbiotic composition by favoring the growth of lactobacilli and inhibiting the growth of human opportunistic pathogens are discussed. Research results suggest that more studies on humans are needed.
本综述聚焦于越橘（Vaccinium vitis-idaea L.）果实酚类化合物在人体体外细胞和体内临床研究中的作用。对越橘、越橘汁/越橘花蜜/发酵越橘汁以及含有活性分子的酚类组分的研究进行了综述。越橘的生物活性物质具有多种抗菌、抗炎、抗蛋白水解、抗癌和抗氧化特性。文中讨论了越橘的发酵以及通过促进乳酸菌生长和抑制人类机会性病原体生长将失调的微生物群调节为更具共生性的组成。研究结果表明，还需要对人体进行更多研究。
