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Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis.

作者信息

Loke S L, Stein C, Zhang X, Avigan M, Cohen J, Neckers L M

出版信息

Curr Top Microbiol Immunol. 1988;141:282-9. doi: 10.1007/978-3-642-74006-0_38.

DOI:10.1007/978-3-642-74006-0_38
PMID:3063445
Abstract
摘要

相似文献

1
Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis.通过脂质体融合将c-myc反义硫代磷酸酯寡脱氧核苷酸递送至培养的造血细胞：c-myc蛋白表达的特异性降低与细胞生长和DNA合成的抑制相关。
Curr Top Microbiol Immunol. 1988;141:282-9. doi: 10.1007/978-3-642-74006-0_38.
2
Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells.c-myc反义硫代磷酸酯寡脱氧核苷酸对恶性胶质瘤细胞的抗增殖作用。
Neurosurgery. 1997 Oct;41(4):908-15. doi: 10.1097/00006123-199710000-00027.
3
[Study on the antisense inhibition effect of liposome-mediated radiolabled antisense oligonucleotides of c-myc mRNA].[脂质体介导的c-myc mRNA放射性标记反义寡核苷酸的反义抑制作用研究]
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Cellular effects of antisense c-myc oligodeoxynucleotides are delivery dependent.反义 c-myc 寡脱氧核苷酸的细胞效应依赖于传递。
Drug Deliv. 1996;3(3):149-54. doi: 10.3109/10717549609029444.
5
Antitumor effect of c-myc antisense phosphorothioate oligodeoxynucleotides on human melanoma cells in vitro and and in mice.c-myc反义硫代磷酸酯寡脱氧核苷酸对人黑色素瘤细胞的体外及小鼠体内抗肿瘤作用
J Natl Cancer Inst. 1996 Apr 3;88(7):419-29. doi: 10.1093/jnci/88.7.419.
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Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.在一种神经上皮瘤细胞系中，对单拷贝N-myc表达进行反义抑制会导致细胞生长减缓，而c-myc蛋白水平却没有降低。
Cancer Res. 1990 Oct 1;50(19):6316-22.
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Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.硫代磷酸酯反义寡核苷酸对c-myc表达的抑制作用表明c-myc在人类乳腺癌生长中起关键作用。
Cancer Res. 1991 Aug 1;51(15):3996-4000.
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Effects of phosphodiester and phosphorothioate antisense oligodeoxynucleotides on cell lines which overexpress c-myc: implications for the treatment of Burkitt's lymphoma.磷酸二酯和硫代磷酸反义寡脱氧核苷酸对过表达c-myc的细胞系的作用：对伯基特淋巴瘤治疗的意义。
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Reduction of c-myc expression by an antisense approach under Cre/loxP switching induces apoptosis in human liver cancer cells.在Cre/loxP开关作用下，通过反义方法降低c-myc表达可诱导人肝癌细胞凋亡。
J Cell Physiol. 2001 Jul;188(1):56-66. doi: 10.1002/jcp.1195.

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Nuclear transport of oligonucleotides in HepG2-cells mediated by protamine sulfate and negatively charged liposomes.硫酸鱼精蛋白和带负电荷脂质体介导的寡核苷酸在HepG2细胞中的核转运。
Pharm Res. 2000 Oct;17(10):1206-11. doi: 10.1023/a:1026410612600.
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Gene interference using antisense oligodeoxynucleotides on whole chick embryos. Optimal ring and roller-bottle culture technique.在整个鸡胚上使用反义寡脱氧核苷酸进行基因干扰。优化的转环和滚瓶培养技术。
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Antisense technology for cancer therapy: does it make sense?用于癌症治疗的反义技术：有意义吗？
Br J Cancer. 1993 May;67(5):869-76. doi: 10.1038/bjc.1993.164.
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Nucleic Acids Res. 1993 Jul 25;21(15):3567-73. doi: 10.1093/nar/21.15.3567.