Antisense technology for cancer therapy: does it make sense?
作者信息
Carter G, Lemoine N R
机构信息
ICRF Oncology Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Br J Cancer. 1993 May;67(5):869-76. doi: 10.1038/bjc.1993.164.
Abstract
摘要
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本文引用的文献
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Oligodeoxynucleotides as inhibitors of gene expression: a review.作为基因表达抑制剂的寡脱氧核苷酸：综述
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An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation.一种与c-myc信使核糖核酸互补的寡聚物可抑制HL-60早幼粒细胞的增殖并诱导其分化。
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Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA.针对c-myc mRNA的反义十五聚脱氧核苷酸可抑制人早幼粒细胞白血病HL-60细胞的增殖及c-myc蛋白的表达。
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Delivery of c-myc antisense phosphorothioate oligodeoxynucleotides to hematopoietic cells in culture by liposome fusion: specific reduction in c-myc protein expression correlates with inhibition of cell growth and DNA synthesis.通过脂质体融合将c-myc反义硫代磷酸酯寡脱氧核苷酸递送至培养的造血细胞：c-myc蛋白表达的特异性降低与细胞生长和DNA合成的抑制相关。
Curr Top Microbiol Immunol. 1988;141:282-9. doi: 10.1007/978-3-642-74006-0_38.
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Specific inhibition of lymphokine biosynthesis and autocrine growth using antisense oligonucleotides in Th1 and Th2 helper T cell clones.使用反义寡核苷酸对Th1和Th2辅助性T细胞克隆中的淋巴因子生物合成和自分泌生长进行特异性抑制。
J Exp Med. 1988 Dec 1;168(6):2309-18. doi: 10.1084/jem.168.6.2309.
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