Department of Ecology, Evolution and Natural Resources, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States.
College of Marine Science, University of South Florida, Saint Petersburg, FL, United States.
Adv Virus Res. 2019;103:71-133. doi: 10.1016/bs.aivir.2018.10.001. Epub 2018 Dec 5.
While single-stranded DNA (ssDNA) was once thought to be a relatively rare genomic architecture for viruses, modern metagenomics sequencing has revealed circular ssDNA viruses in most environments and in association with diverse hosts. In particular, circular ssDNA viruses encoding a homologous replication-associated protein (Rep) have been identified in the majority of eukaryotic supergroups, generating interest in the ecological effects and evolutionary history of circular Rep-encoding ssDNA viruses (CRESS DNA) viruses. This review surveys the explosion of sequence diversity and expansion of eukaryotic CRESS DNA taxonomic groups over the last decade, highlights similarities between the well-studied geminiviruses and circoviruses with newly identified groups known only through their genome sequences, discusses the ecology and evolution of eukaryotic CRESS DNA viruses, and speculates on future research horizons.
虽然单链 DNA（ssDNA）曾经被认为是病毒中相对罕见的基因组结构，但现代宏基因组测序已经揭示了在大多数环境中和与各种宿主相关的环状 ssDNA 病毒。特别是，在大多数真核超群中已经鉴定出编码同源复制相关蛋白（Rep）的环状 ssDNA 病毒，这引起了人们对环状 Rep 编码 ssDNA 病毒（CRESS DNA）病毒的生态效应和进化历史的兴趣。本文综述了过去十年中序列多样性的爆炸式增长和真核 CRESS DNA 分类群的扩展，强调了研究较为充分的双生病毒科和圆环病毒科与新发现的仅通过基因组序列了解的群体之间的相似性，讨论了真核 CRESS DNA 病毒的生态学和进化，并推测了未来的研究方向。
