Rahimi Vida, Mohamadkhani Ghassem, Alaghband-Rad Javad, Kermani Fatemeh Ranjbar, Nikfarjad Hossien, Marofizade Saman
Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Piche-Shemiran, Enghelab Ave., 1148965141, Tehran, Iran.
Department of Psychiatry, Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Exp Brain Res. 2019 Mar;237(3):873-882. doi: 10.1007/s00221-019-05471-9. Epub 2019 Jan 12.
In recent years, transcranial direct current stimulation (tDCS) has been used as a safe and non-invasive method for children and adolescents with dyslexia. Our aim in this study was to investigate the effect of tDCS on variables of temporal resolution and speech long-latency auditory-evoked potentials with two electrode arrays on superior temporal gyrus (STG). A total of 17 children and adolescents with dyslexia (age 9-12 years) were included in our study. All participants underwent the gap in noise (GIN) test and long-latency auditory-evoked potentials recording at baseline without applying tDCS, sham (placebo), and after 20 min of exposure to two different tDCS polarities: anode of tDCS on left STG/cathode on the right shoulder and anode on the left STG/cathode on right STG to enhance left lateralization. Our results showed significant decreases in the threshold value and increases in the percentages of correct responses in the GIN test. We also found reduced latency and increased amplitude of the P1, N1, and P2 waves in two stimulation polarities compared with baseline and sham. Our findings indicate the potential role of tDCS on improving the characteristics of central auditory processing, especially temporal information processing in children and adolescents with dyslexia, and could introduce a new strategy to facilitate the rehabilitation of central auditory processing disorders in future.
近年来，经颅直流电刺激（tDCS）已被用作一种针对诵读困难儿童和青少年的安全且无创的方法。本研究的目的是通过在颞上回（STG）使用两个电极阵列，研究tDCS对时间分辨率变量和言语长潜伏期听觉诱发电位的影响。我们的研究共纳入了17名患有诵读困难的儿童和青少年（年龄9 - 12岁）。所有参与者在未施加tDCS、假刺激（安慰剂）的基线状态下，以及在暴露于两种不同tDCS极性（左侧STG为阳极/右侧肩部为阴极，以及左侧STG为阳极/右侧STG为阴极以增强左侧化）20分钟后，均接受了噪声间隙（GIN）测试和长潜伏期听觉诱发电位记录。我们的结果显示，GIN测试中的阈值显著降低，正确反应百分比增加。我们还发现，与基线和假刺激相比，两种刺激极性下P1、N1和P2波的潜伏期缩短，波幅增加。我们的研究结果表明，tDCS在改善诵读困难儿童和青少年的中枢听觉处理特征，特别是时间信息处理方面具有潜在作用，并可能在未来引入一种促进中枢听觉处理障碍康复的新策略。
