可卡因相关致死性过量中芬太尼的存在增加：对预防的影响。
Increased Presence of Fentanyl in Cocaine-Involved Fatal Overdoses: Implications for Prevention.
机构信息
Bureau of Alcohol and Drug Use Prevention, Care, and Treatment, New York City Department of Health and Mental Hygiene, 42-09 28th St, 19th Floor, Queens, New York, NY, 11101, USA.
出版信息
J Urban Health. 2019 Feb;96(1):49-54. doi: 10.1007/s11524-018-00343-z.
After remaining stable from 2010 to 2014, the rate of cocaine-involved overdose death increased sharply from 2015 to 2016. This study aims to determine the contribution of opioids, and fentanyl in particular, to the increase in cocaine-involved overdose death from 2015 to 2016. Using New York City death certificate data linked to medical examiner toxicology data, we identified all overdose deaths where post-mortem toxicology results were positive for cocaine from 2010 to 2016. We analyzed cocaine-involved overdose deaths by co-occurring substances. Age-adjusted rates per 100,000 residents were calculated for 6-month intervals from 2010 to 2016. Data suggest that increased deaths involving opioids, specifically fentanyl, accounted for most of the increase in cocaine-involved deaths from 2015 to 2016.
在 2010 年至 2014 年期间保持稳定后，2015 年至 2016 年可卡因相关用药过量死亡人数急剧增加。本研究旨在确定阿片类药物（特别是芬太尼）对 2015 年至 2016 年可卡因相关用药过量死亡人数增加的贡献。我们使用纽约市死亡证明数据与法医毒理学数据进行关联，确定了 2010 年至 2016 年所有死后毒理学检测结果呈可卡因阳性的用药过量死亡案例。我们通过同时存在的物质对可卡因用药过量死亡案例进行分析。我们计算了 2010 年至 2016 年每六个月间隔的每 10 万居民年龄调整后的发生率。数据表明，涉及阿片类药物（特别是芬太尼）的死亡人数增加是 2015 年至 2016 年可卡因相关死亡人数增加的主要原因。
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