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Oncotarget. 2017 Sep 7;8(47):81873-81879. doi: 10.18632/oncotarget.20704. eCollection 2017 Oct 10.
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Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells.阴道毛滴虫α-辅肌动蛋白2通过调节性T细胞产生白细胞介素-10诱导耐受性树突状细胞来调节宿主免疫反应。
Korean J Parasitol. 2017 Aug;55(4):375-384. doi: 10.3347/kjp.2017.55.4.375. Epub 2017 Aug 31.
4
Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy.类风湿性关节炎：病因学、细胞因子作用和药物治疗学的最新进展。
Biomed Pharmacother. 2017 Aug;92:615-633. doi: 10.1016/j.biopha.2017.05.055. Epub 2017 Jun 3.
5
Periodontitis increases rheumatic factor serum levels and citrullinated proteins in gingival tissues and alter cytokine balance in arthritic rats.牙周炎会增加风湿因子血清水平和牙龈组织中的瓜氨酸化蛋白，并改变关节炎大鼠体内的细胞因子平衡。
PLoS One. 2017 Mar 30;12(3):e0174442. doi: 10.1371/journal.pone.0174442. eCollection 2017.
6
Th17 and CD24CD27 regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis.辅助性T细胞17（Th17）和CD24CD27调节性B淋巴细胞是类风湿关节炎中对生物制剂反应的生物标志物。
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8
Macrophage heterogeneity in the context of rheumatoid arthritis.类风湿关节炎背景下的巨噬细胞异质性。
Nat Rev Rheumatol. 2016 Aug;12(8):472-85. doi: 10.1038/nrrheum.2016.91. Epub 2016 Jul 7.
9
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10
M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide.源自THP-1细胞的M1和M2巨噬细胞对癌细胞对依托泊苷的反应具有不同的调节作用。
BMC Cancer. 2015 Aug 8;15:577. doi: 10.1186/s12885-015-1546-9.

血管活性肠肽是维持免疫调节单核细胞免疫调节功能所必需的。

Vasoactive intestinal peptide is required in the maintenance of immune regulatory competency of immune regulatory monocytes.

机构信息

Department of Respirology, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.

Research Center of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.

出版信息

Clin Exp Immunol. 2019 May;196(2):276-286. doi: 10.1111/cei.13259. Epub 2019 Jan 30.

DOI:10.1111/cei.13259
PMID:30636174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6468183/
Abstract

Dysfunction of the immune regulatory system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Vasoactive intestinal peptide (VIP) has multiple bioactivities. This study aims to investigate the role of VIP in the maintenance of the immune regulatory capacity of monocytes (Mos). Human peripheral blood samples were collected from RA patients and healthy control (HC) subjects. Mos and CD14 CD71 CD73 CD25 regulatory Mos (RegMos) were isolated from the blood samples and characterized by flow cytometry. A rat RA model was developed to test the role of VIP in the maintenance of the immune regulatory function of Mos. The results showed that RegMos of HC subjects had immune suppressive functions. RegMos of RA patients expressed less interleukin (IL)-10 and showed an incompetent immune regulatory capacity. Serum levels of VIP were lower in RA patients, which were positively correlated with the expression of IL-10 in RegMos. In-vitro experiments showed that the IL-10 mRNA decayed spontaneously in RegMos, which could be prevented by the presence of VIP in the culture. VIP suppressed the effects of tristetraprolin (TTP) on inducing IL-10 mRNA decay in RegMos. Administration of VIP inhibited experimental RA in rats through restoring the IL-10 expression in RegMos. RegMos have immune suppressive functions. VIP is required in maintaining IL-10 expression in RegMos. The data suggest that VIP has translational potential in the treatment of immune disorders such as RA.

摘要

免疫调节系统功能障碍在类风湿关节炎（RA）的发病机制中起着重要作用。血管活性肠肽（VIP）具有多种生物活性。本研究旨在探讨 VIP 在维持单核细胞（Mos）免疫调节能力中的作用。从 RA 患者和健康对照（HC）受试者中采集外周血样本。通过流式细胞术从血液样本中分离 Mos 和 CD14 CD71 CD73 CD25 调节性 Mos（RegMos），并对其进行鉴定。建立大鼠 RA 模型以测试 VIP 在维持 Mos 免疫调节功能中的作用。结果表明，HC 受试者的 RegMos 具有免疫抑制功能。RA 患者的 RegMos 表达较少的白细胞介素（IL）-10，表现出功能失调的免疫调节能力。RA 患者的血清 VIP 水平较低，与 RegMos 中 IL-10 的表达呈正相关。体外实验表明，RegMos 中的 IL-10 mRNA 自发衰减，而 VIP 的存在可防止这种衰减。VIP 抑制了 tristetraprolin（TTP）在 RegMos 中诱导 IL-10 mRNA 衰减的作用。VIP 通过恢复 RegMos 中 IL-10 的表达来抑制大鼠实验性 RA。RegMos 具有免疫抑制功能。VIP 是维持 RegMos 中 IL-10 表达所必需的。这些数据表明，VIP 在治疗 RA 等免疫紊乱方面具有转化潜力。