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阴道毛滴虫α-辅肌动蛋白2通过调节性T细胞产生白细胞介素-10诱导耐受性树突状细胞来调节宿主免疫反应。

Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells.

作者信息

Lee Hye-Yeon, Kim Juri, Ryu Jae-Sook, Park Soon-Jung

机构信息

Department of Environmental Medical Biology and Institute of Tropical Medicine, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul 04763, Korea.

出版信息

Korean J Parasitol. 2017 Aug;55(4):375-384. doi: 10.3347/kjp.2017.55.4.375. Epub 2017 Aug 31.

DOI:10.3347/kjp.2017.55.4.375
PMID:28877568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5594722/
Abstract

Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2, Tvα-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tvα-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tvα-actinin 2 antibodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tvα-actinin 2 protein. Both T. vaginalis and rTvα-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4+CD25- regulatory T cells (Treg cells) incubated with rTvα-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tvα-actinin 2 modulates immune responses via IL-10 production by Treg cells.

摘要

阴道毛滴虫是一种能在宿主体内引发强烈免疫反应的病原体。阴道毛滴虫α-辅肌动蛋白2（Tvα-actinin 2）已被用于诊断滴虫病。本研究旨在探讨Tvα-actinin 2作为一种抗原分子在诱导人体免疫反应中的作用。使用抗Tvα-actinin 2抗体进行的蛋白质免疫印迹分析表明其存在于阴道毛滴虫的分泌蛋白中。采用酶联免疫吸附测定法（ELISA）来检测经阴道毛滴虫或Tvα-actinin 2蛋白刺激的阴道上皮细胞、前列腺细胞、小鼠树突状细胞（DCs）或T细胞产生的细胞因子。阴道毛滴虫和重组Tvα-actinin 2（rTvα-actinin 2）均能诱导上皮细胞系产生细胞因子，包括白细胞介素-10（IL-10）。此外，与经rTvα-actinin 2处理的DCs共同孵育的CD4+CD25-调节性T细胞（Treg细胞）产生了高水平的IL-10。这些数据表明，Tvα-actinin 2通过Treg细胞产生IL-10来调节免疫反应。

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Comparison between mixed lysate antigen and α-actinin antigen in ELISA for serodiagnosis of trichomoniasis.用于滴虫病血清学诊断的酶联免疫吸附测定中混合裂解物抗原与α-肌动蛋白抗原的比较。
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Epitopes of the highly immunogenic Trichomonas vaginalis α-actinin are serodiagnostic targets for both women and men.阴道毛滴虫高度免疫原性的α-肌动蛋白表位是女性和男性血清学诊断的靶标。
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