School of Healthy , Siirt University , Siirt , Turkey.
Crit Rev Anal Chem. 2019;49(5):403-414. doi: 10.1080/10408347.2018.1538768. Epub 2019 Jan 12.
Prostate cancer is the second most common malignant type of cancer in men and fifth among fatal types of cancer. Because drugs used in prostate cancer, such as in many other drugs, are also present in low concentrations in body fluids, it is important to develop highly sensitive and sensitive methods that allow the correct amount of prostate cancer drugs to be determined at low concentrations in biological specimens. Electrochemical approaches for the quantitation of prostate cancer drugs have several advantages over other common techniques, including sensitive, selective, fast, broad linear concentration range. Over the years, various modified working electrodes such as graphite, glassy carbon, carbon paste electrode, carbon composites, and nanotubes have been developed and used in various forms for electroanalytical determinations of prostate cancer drugs. One of the important developments in the electroanalytical chemistry is the surface modification of electrodes. The various sensing strategies for the electrochemical detection techniques such as voltammetry, polarography, amperometry, potentiometry have been used for prostate cancer drugs. This review focuses on studies published over the past years on sensitive and selective detection of prostate cancer drugs in biological fluids and dosage forms using electrochemical methods.
前列腺癌是男性中第二常见的恶性癌症类型，也是致命癌症类型中的第五种。由于前列腺癌药物（如许多其他药物）在体液中的浓度也很低，因此开发高度敏感和灵敏的方法来确定生物标本中低浓度的前列腺癌药物的正确剂量非常重要。电化学方法在定量前列腺癌药物方面具有许多优于其他常见技术的优点，包括灵敏、选择性、快速、宽线性浓度范围。多年来，已经开发并使用了各种经过修饰的工作电极，如石墨、玻碳、碳糊电极、碳复合材料和纳米管，以各种形式用于电化学测定前列腺癌药物。电分析化学的一个重要发展是电极的表面修饰。各种电化学检测技术（如伏安法、极谱法、电流法、电位法）的传感策略已被用于前列腺癌药物的检测。本综述重点介绍了过去几年使用电化学方法在生物流体和剂型中对前列腺癌药物进行灵敏和选择性检测的研究。
