Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
Brain Topogr. 2014 Mar;27(2):307-17. doi: 10.1007/s10548-013-0306-x. Epub 2013 Jul 30.
It is well known that the P300 amplitude is reduced in schizophrenia patients, which may reflect the pathophysiology and symptom severity of schizophrenia, particularly related to negative symptoms. However, the relationship between the underlying neural generator of the P300 and symptomatic outcomes are not yet fully understood. This study aimed to verify the abnormal P300 of schizophrenia in terms of its source activation to and further examine the relationship between reduced source activation and symptom severity of patients. For this purpose, the P300 was recorded from 34 patients with schizophrenia and matched healthy controls using an auditory oddball paradigm. We found that the P300 amplitude of schizophrenia patients was significantly decreased along the midline electrodes and both bilateral temporal areas compared with healthy controls. In comparing the source activation between the two groups, schizophrenia patients showed decreased source activation predominantly over the left hemisphere, including the cingulate, inferior occipital gyrus, middle occipital gyrus, middle temporal gyrus, posterior cingulate, precuneus, and superior occipital gyrus. Furthermore, we found that the decreased activation of the contrasted areas showed significant negative correlation with PANSS negative symptom scores in the middle temporal gyrus, posterior cingulate, precuneus, and superior occipital gyrus. Our findings suggest that the reduced P300 source activation in schizophrenia might reflect deficits in fronto-temporal-parietal circuit.
众所周知，精神分裂症患者的 P300 波幅降低，这可能反映了精神分裂症的病理生理学和症状严重程度，尤其是与阴性症状有关。然而，P300 的潜在神经发生器与症状结果之间的关系尚未完全理解。本研究旨在通过对 P300 的源激活进行验证，从而进一步检查精神分裂症患者中 P300 波幅降低与症状严重程度之间的关系。为此，本研究使用听觉Oddball 范式，从 34 名精神分裂症患者和匹配的健康对照组中记录了 P300。我们发现，与健康对照组相比，精神分裂症患者的 P300 波幅在中线电极和双侧颞区显著降低。在比较两组的源激活时，精神分裂症患者表现出主要在左半球的源激活减少，包括扣带回、下枕叶、中枕叶、中颞叶、后扣带回、楔前叶和上枕叶。此外，我们发现，与健康对照组相比，与中颞叶、后扣带回、楔前叶和上枕叶的 PANSS 阴性症状评分呈显著负相关。我们的研究结果表明，精神分裂症患者 P300 源激活减少可能反映了额颞顶叶回路的缺陷。
