Khorana A B, Patel Y
Department of Psychiatry, Medical College, Baroda.
Indian J Physiol Pharmacol. 1988 Oct-Dec;32(4):293-8.
A double blind comparative study was conducted to evaluate the efficacy and safety of penfluridol and trifluoperazine in patients of chronic schizophrenia. Penfluridol was administered once weekly while trifluoperazine was administered twice daily by preparing identical capsules. The data revealed that both the compounds were similarly effective in maintaining control of symptoms of chronic schizophrenia. However, penfluridol has a definite advantage over trifluoperazine since it is administered once a week instead of twice a day.
开展了一项双盲对照研究，以评估五氟利多和三氟拉嗪对慢性精神分裂症患者的疗效和安全性。五氟利多每周给药一次，而三氟拉嗪通过制备相同胶囊每日给药两次。数据显示，两种化合物在维持慢性精神分裂症症状控制方面同样有效。然而，五氟利多比三氟拉嗪具有明显优势，因为它每周给药一次而非每日给药两次。
