Claghorn J L, Mathew R J, Mirabi M
J Clin Psychiatry. 1979 Feb;40(2):107-9.
Penfluridol is a diphenylbutylpiperdine derivative with a half-life of sixty-six (66) hours. The present study was designed to determine its efficacy for the maintenance of schizophrenia. In a 52 week double-blind study, once weekly doses of penfluridol were compared with once daily doses of chlorpromazine in 56 schizophrenic patients receiving maintenance treatment on an outpatient basis. Both drugs were similar in their clinical effectiveness; no major side effects occurred with either drug.
五氟利多是一种二苯基丁基哌啶衍生物，半衰期为66小时。本研究旨在确定其对维持治疗精神分裂症的疗效。在一项为期52周的双盲研究中，将56例接受门诊维持治疗的精神分裂症患者每周一次剂量的五氟利多与每日一次剂量的氯丙嗪进行比较。两种药物的临床疗效相似；两种药物均未出现重大副作用。
