Magliano Carlos Alberto da Silva, Monteiro Andrea Libório, de Oliveira Rebelo Amanda Rebeca, de Aguiar Pereira Claudia Cristina
Instituto Nacional de Cardiologia, INC, Rio de Janeiro, Brazil.
Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Illinois, USA.
Patient Prefer Adherence. 2018 Dec 24;13:29-35. doi: 10.2147/PPA.S188268. eCollection 2019.
Current recommendations regarding the best treatment option for coronary revascularization are usually based on composite outcomes that were not selected or weighed with patients thence they may fail in representing patients' preferences adequately. This systematic review aimed to appraise existing literature surrounding stated preference (SP) regarding coronary revascularization.
Studies related to SP regarding coronary revascularization were searched on Medline, Embase and Lilacs databases. Two reviewers screened all titles independently, and consensus resolved any disagreements. Of 735 total citations, six studies were included and qualitatively synthesized. Notably, the attributes most often cited in these studies coincided with those already used in clinical trials (death, myocardial infarction, stroke and redo revascularization). Half of the studies analyzed the use of composite endpoints and showed the necessity to review this practice since the attributes are weighed differently, and there is a disagreement between patients and physicians. Also, a large variety of methods were used to elicitate and value the attributes such as rating, ranking, standard gamble, willingness to pay, and discrete choice experiments.
Despite a large number of studies comparing revascularization treatment efficacy, there are just a few focusing on patients' preferences. The selection of outcomes to be considered in the trade-off between treatment options and how to weigh them properly, taking into consideration patients' preferences, need to be explored in future trials.
目前关于冠状动脉血运重建最佳治疗方案的建议通常基于综合结果,这些结果并非根据患者情况选择或权衡得出,因此可能无法充分体现患者的偏好。本系统评价旨在评估围绕冠状动脉血运重建的既定偏好(SP)的现有文献。
在Medline、Embase和Lilacs数据库中检索与冠状动脉血运重建的SP相关的研究。两名 reviewers 独立筛选所有标题,如有分歧则通过协商解决。在总共735条引用文献中,纳入了6项研究并进行定性综合分析。值得注意的是,这些研究中最常引用的属性与临床试验中已经使用的属性一致(死亡、心肌梗死、中风和再次血运重建)。一半的研究分析了复合终点的使用情况,并表明有必要重新审视这种做法,因为各属性的权重不同,且患者与医生之间存在分歧。此外,还使用了多种方法来引出和评估这些属性,如评分、排序、标准博弈、支付意愿和离散选择实验。
尽管有大量研究比较血运重建治疗效果,但关注患者偏好的研究却很少。在未来的试验中,需要探索在治疗方案权衡中应考虑的结果选择以及如何根据患者偏好进行适当权衡。