Sarecka-Hujar Beata, Kopyta Ilona
Department of Pharmaceutical Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland,
Department of Paediatric Neurology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
Neuropsychiatr Dis Treat. 2018 Dec 24;15:95-103. doi: 10.2147/NDT.S169579. eCollection 2019.
Seizures and epilepsy are quite a common outcome of arterial ischemic stroke (AIS) both in pediatric and adult patients, with distinctly higher occurrence in children. These poststroke consequences affect patients' lives, often causing disability. Poststroke seizure (PSS) may also increase mortality in patients with AIS. Early PSS (EPSS) occurring up to 7 days after AIS, late PSS (LPSS) occurring up to 2 years after the onset of AIS, as well as poststroke epilepsy (PSE) can be distinguished. However, the exact definition and cutoff point for PSE should be determined. A wide range of risk factors for seizures and epilepsy after AIS are still being detected and analyzed. More accurate knowledge on risk factors for PSS and PSE as well as possible prediction of epileptic seizures after the onset of AIS may have an impact on improving the prevention and treatment of PSE. The aim of the present review was to discuss current perspectives on diagnosis and treatment of PSS and PSE, both in adult and paediatric patients.
癫痫发作和癫痫是小儿及成年动脉缺血性卒中（AIS）患者相当常见的后果，在儿童中的发生率明显更高。这些卒中后后果会影响患者生活，常导致残疾。卒中后癫痫发作（PSS）也可能增加AIS患者的死亡率。可区分出AIS后7天内发生的早期PSS（EPSS）、AIS发病后2年内发生的晚期PSS（LPSS）以及卒中后癫痫（PSE）。然而，PSE的确切定义和临界值仍有待确定。仍在检测和分析AIS后癫痫发作和癫痫的多种危险因素。对PSS和PSE危险因素的更准确了解以及AIS发病后癫痫发作的可能预测可能会对改善PSE的预防和治疗产生影响。本综述的目的是讨论成人和小儿患者PSS和PSE诊断与治疗的当前观点。
