Johnson E L, Reynolds D L, Wright D S, Pachla L A
Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105.
J Chromatogr Sci. 1988 Aug;26(8):372-9. doi: 10.1093/chromsci/26.8.372.
This paper describes strategies to rapidly develop sensitive and selective preparations using manual and robotic liquid-solid isolation (LSI) methods. LSI procedures offer selective isolation of drug or metabolites from complex matrices and are applicable to many pharmaceutical compounds. The beneficial effect of weighted linear regression is described, and several data reduction techniques are contrasted.
本文介绍了使用手动和机器人液固分离（LSI）方法快速开发灵敏且具选择性的制剂的策略。LSI程序可从复杂基质中选择性分离药物或代谢物，适用于多种药物化合物。文中描述了加权线性回归的有益效果，并对比了几种数据缩减技术。
