同步经颅磁刺激治疗成人抑郁症的脑活动与临床结局：一项探索性研究。
Brain Activity and Clinical Outcomes in Adults With Depression Treated With Synchronized Transcranial Magnetic Stimulation: An Exploratory Study.
机构信息
Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
出版信息
Neuromodulation. 2019 Dec;22(8):894-897. doi: 10.1111/ner.12914. Epub 2019 Jan 13.
BACKGROUND
Synchronized transcranial magnetic stimulation (sTMS) imparts low-amplitude magnetic stimulation matched to each patient's individual alpha frequency. It may act through entrainment of brain oscillations.
OBJECTIVES
To explore sTMS effects on neurophysiology with electroencephalography (EEG) in adults with major depressive disorder.
METHODS
As an ancillary study to a clinical trial of sTMS, EEGs were recorded at baseline and at one and six weeks of treatment. Associations between EEG measures and clinical symptoms were examined.
RESULTS
Absolute and relative power measures did not differ significantly between active and sham groups and did not change significantly over time. Changes occurring over six weeks in alpha current source density at anterior and central midline voxels were significantly correlated with changes in symptoms in subjects treated with active but not sham sTMS.
CONCLUSION
Neurophysiologic measures suggest that active but not sham sTMS engages brain targets, and that target engagement is related to treatment outcome.
背景
同步经颅磁刺激（sTMS）施加与每个患者的个体阿尔法频率匹配的低幅度磁场刺激。它可能通过脑振荡的同步而发挥作用。
目的
探索同步经颅磁刺激对成年重性抑郁障碍患者神经生理学的影响，通过脑电图（EEG）进行研究。
方法
作为同步经颅磁刺激临床试验的辅助研究，在基线和治疗的第 1 周和第 6 周记录脑电图。检查脑电图测量值与临床症状之间的相关性。
结果
在活跃组和假刺激组之间，绝对和相对功率测量值没有显著差异，且随时间变化没有显著变化。在接受活跃但非假刺激 sTMS 治疗的患者中，前中央中线体素的阿尔法电流源密度在 6 周内的变化与症状的变化显著相关。
结论
神经生理学测量表明，活跃但非假刺激 sTMS 作用于大脑靶标，且靶标作用与治疗效果相关。
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