Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.
J Clin Hypertens (Greenwich). 2019 Feb;21(2):299-306. doi: 10.1111/jch.13470. Epub 2019 Jan 13.
Previously, we reported that magnetic stimulation of carotid sinus (MSCS) could lower arterial pressure in rabbits. In this randomized, sham-controlled pilot study, we evaluated the effects of MSCS on blood pressure in pre-hypertensive and hypertensive subjects. A total of 15 subjects with blood pressure higher than 130/80 mm Hg were randomized to receive sham or 1Hz MSCS. The changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP) during treatment were compared between groups. The heart rate variability (HRV) and baroreflex sensitivity (BRS) before, during, and after treatments were analyzed. Reduction of SBP was significantly greater in subjects with MSCS than those with sham stimulation (6.6 ± 0.4 vs -2.5 ± 0.4 mm Hg, P < 0.001). Reduction of DBP was significantly greater in subjects with MSCS than those with sham stimulation (1.2 ± 0.2 vs -2.8 ± 0.2 mm Hg, P < 0.001). Reduction of MAP was significantly greater in subjects with MSCS than those with sham stimulation (1.4 ± 0.3 mm Hg vs -4.0 ± 0.3 mm Hg, P < 0.001). Reduction of HR was significantly greater in subjects with MSCS than those with sham stimulation (0.5 ± 0.5 vs -1.9 ± 0.3 beats/min, P = 0.002). BRS increased from 6.85 ± 0.77 to 8.79 ± 0.95 ms/mm Hg after MSCS compared with that at baseline (P = 0.027). Thus, MSCS can lower blood pressure and heart rate in pre-hypertensive and hypertensive subject, warranting further study for establishing MSCS as a treatment for hypertension.
先前，我们曾报道过颈动脉窦磁刺激（MSCS）可以降低兔的动脉血压。在这项随机、假刺激对照的初步研究中，我们评估了 MSCS 对高血压前期和高血压患者血压的影响。共有 15 名血压高于 130/80mmHg 的患者被随机分为假刺激或 1Hz MSCS 组。比较两组治疗期间收缩压（SBP）、舒张压（DBP）、平均血压（MAP）的变化。分析治疗前后心率变异性（HRV）和压力感受性反射敏感性（BRS）。MSCS 组的 SBP 降低明显大于假刺激组（6.6±0.4 与-2.5±0.4mmHg，P<0.001）。MSCS 组的 DBP 降低明显大于假刺激组（1.2±0.2 与-2.8±0.2mmHg，P<0.001）。MSCS 组的 MAP 降低明显大于假刺激组（1.4±0.3mmHg 与-4.0±0.3mmHg，P<0.001）。MSCS 组的 HR 降低明显大于假刺激组（0.5±0.5 与-1.9±0.3 次/分，P=0.002）。与基线相比，MSCS 后 BRS 从 6.85±0.77 增加到 8.79±0.95ms/mm Hg（P=0.027）。因此，MSCS 可降低高血压前期和高血压患者的血压和心率，有必要进一步研究将 MSCS 作为高血压的治疗方法。
