ShamsEldeen Asmaa M, Hosny Sara A, Maghib Khaled, Ashour Hend
Department of Physiology, Cairo University, Cairo 11956, Egypt.
Department of Histology and Cell Biology, Faculty of Medicine, Cairo University, Cairo 11956, Egypt.
World J Stem Cells. 2025 Aug 26;17(8):107480. doi: 10.4252/wjsc.v17.i8.107480.
Mesenchymal stem cells (MSCs) derived from bone marrow or adipose tissue have promising potential in regenerative medicine. The regenerative capacity of MSCs depends on their successful migration and engraftment at the injured site. Several preclinical and clinical studies have reported that MSCs effectively treat cardiac dysfunction. However, significant obstacles to MSC homing include peripheral sequestration and low survival rates. MSC-secreted extracellular vesicles exhibit effects similar to those of MSCs, contributing to cellular proliferation, differentiation, and various paracrine functions. This review explores the molecular pathways and mechanisms by which MSCs and extracellular vesicles modulate cardiac injuries. Additionally, we discuss the challenges associated with MSC homing and various strategies to enhance the process.
源自骨髓或脂肪组织的间充质干细胞（MSCs）在再生医学中具有广阔的应用前景。间充质干细胞的再生能力取决于它们能否成功迁移并植入损伤部位。多项临床前和临床研究报告称，间充质干细胞能有效治疗心脏功能障碍。然而，间充质干细胞归巢面临的重大障碍包括外周滞留和低存活率。间充质干细胞分泌的细胞外囊泡表现出与间充质干细胞类似的作用，有助于细胞增殖、分化以及各种旁分泌功能。本综述探讨了间充质干细胞和细胞外囊泡调节心脏损伤的分子途径和机制。此外，我们还讨论了与间充质干细胞归巢相关的挑战以及增强这一过程的各种策略。
