强化维生素 D 的食物对骨密度和血清骨生物标志物的功效：干预性研究的系统评价和荟萃分析。

Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies.

机构信息

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Student Research Committee, Department and Faculty of Nutrition Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Crit Rev Food Sci Nutr. 2020;60(7):1094-1103. doi: 10.1080/10408398.2018.1558172. Epub 2019 Jan 13.

DOI:10.1080/10408398.2018.1558172

PMID:30638043

Abstract

Vitamin D fortified foods (VDFs) were taken into consideration due to the high prevalence of osteoporosis worldwide. However, the efficacy of VDFs on bone health has not been fully examined. The current meta-analysis was conducted in order to summarize the impacts of VDFs on serum 25-hydroxyvitamin D (25(OH)D), bone mineral density (BMD), and bone turnover markers (BTM). A systematic search up to October 2017 was done via PubMed and Scopus search engines. To pool mean differences, random-effects model (the DerSimonian-Laird estimator) was used. Heterogeneity among studies was examined by Cochrane Q test. 20 trials involving 1786 subjects were included in this meta-analysis. Based on random effect model, there were significant effects of VDFs on serum 25(OH)D (MD:16.94 nmol/L 95% CI: 13.38, 20.50; < 0.001, = 99.0%), BMD (MD: 0.03 gr/cm; 95% CI: (0.02, 0.05); < 0.001, = 58.8%) and paratormone hormone (PTH; MD:-9.22; 95% CI: (-14.97, -3.46); = 0.002, = 98.8%). VDFs may increase serum 25(OH)D and BMD while decrease serum PTH levels. We did not find any beneficial effect of VDFs on BTM.

摘要

由于骨质疏松症在全球的高患病率，添加维生素 D 强化食品（VDFs）进行考虑。然而，VDFs 对骨骼健康的疗效尚未得到充分研究。本荟萃分析旨在总结 VDFs 对血清 25-羟维生素 D（25（OH）D）、骨密度（BMD）和骨转换标志物（BTM）的影响。通过 PubMed 和 Scopus 搜索引擎进行了截至 2017 年 10 月的系统搜索。为了汇总均值差异，使用随机效应模型（DerSimonian-Laird 估计量）。通过 Cochrane Q 检验检查研究间的异质性。本荟萃分析纳入了 20 项涉及 1786 名受试者的试验。基于随机效应模型，VDFs 对血清 25（OH）D（MD：16.94 nmol/L 95% CI：13.38，20.50； < 0.001， = 99.0%）、BMD（MD：0.03 gr/cm；95% CI：（0.02，0.05）； < 0.001， = 58.8%）和甲状旁腺激素（PTH；MD：-9.22；95% CI：（-14.97，-3.46）； = 0.002， = 98.8%）有显著影响。VDFs 可能增加血清 25（OH）D 和 BMD，同时降低血清 PTH 水平。我们没有发现 VDFs 对 BTM 有任何有益作用。