Velling V A, Shklyaruk S P
Physiological Division, I.P. Pavlov Scientific Research Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad.
Neurosci Behav Physiol. 1988 Sep-Oct;18(5):369-75. doi: 10.1007/BF01193880.
We investigated the possibility of modifying the functional state of the brain with the aid of focused ultrasound and studied various regimes of its action. A specific pattern in the effect of focused ultrasonic action was discovered with regard to its intensity: the effect is absent at low (less than 0.1 mW/cm2) intensities; activation of bioelectrical activity in the brain takes place at intensities from 1 to 100 mW/cm2; and suppression of the ECoG takes place at intensities from 1 to 100 W/cm2. On the basis of our own data and the data in the literature, we suggest that the mechanism of ultrasound action is based upon changes in the permeability of neuronal membranes leading, after a chain of intracellular molecular reactions, to a subsequent general de- or hyperpolarization of the membranes of neuronal populations and to a change in the bioelectrical activity of the brain.
我们研究了借助聚焦超声改变大脑功能状态的可能性，并研究了其各种作用机制。发现聚焦超声作用效果随强度呈现出特定模式：低强度（小于0.1 mW/cm²）时无效果；强度在1至100 mW/cm²时大脑生物电活动被激活；强度在1至100 W/cm²时皮层脑电图受到抑制。基于我们自己的数据以及文献中的数据，我们认为超声作用机制是基于神经元膜通透性的变化，在一系列细胞内分子反应之后，导致神经元群体膜随后普遍去极化或超极化，并引起大脑生物电活动的改变。
