The National Creative Research Initiative Center for Intelligent Hybrids, School of Chemical and Biological Engineering , Seoul National University , Seoul 08826 , Republic of Korea.
Institute of Molecular Biology and Genetics, School of Chemical and Biological Engineering , Seoul National University , Seoul 08826 , Republic of Korea.
ACS Appl Mater Interfaces. 2019 Feb 13;11(6):6550-6560. doi: 10.1021/acsami.8b20092. Epub 2019 Jan 30.
Anti-biofouling has been improved by passive or active ways. Passive antifouling strategies aim to prevent the initial adsorption of foulants, while active strategies aim to eliminate proliferative fouling by destruction of the chemical structure and inactivation of the cells. However, neither passive antifouling strategies nor active antifouling strategies can solely resist biofouling due to their inherent limitations. Herein, we successfully developed multimodal antibacterial surfaces for waterborne and airborne bacteria with the benefit of a combination of antiadhesion (passive) and bactericidal (active) properties of the surfaces. We elaborated multifunctionalizable porous amine-reactive (PAR) polymer films from poly(pentafluorophenyl acrylate) (PPFPA). Pentafluorophenyl ester groups in the PAR films facilitate creation of multiple functionalities through a simple postmodification under mild condition, based on their high reactivity toward various primary amines. We introduced amine-containing poly(dimethylsiloxane) (amine-PDMS) and dopamine into the PAR films, resulting in infusion of antifouling silicone oil lubricants and formation of bactericidal silver nanoparticles (AgNPs), respectively. As a result, the PAR film-based lubricant-infused AgNPs-incorporated surfaces demonstrate outstanding antibacterial effects toward both waterborne and airborne Escherichia coli, suggesting a new door for development of an effective multimodal anti-biofouling surface.
通过被动或主动的方式提高了抗生物污损性。被动抗污损策略旨在防止污染物的初始吸附，而主动策略旨在通过破坏化学结构和使细胞失活来消除增殖性污损。然而，由于其固有局限性，被动抗污损策略和主动抗污损策略都不能单独抵抗生物污损。在此，我们成功地开发了用于水相和空气相细菌的多模式抗菌表面，得益于表面的抗粘连（被动）和杀菌（主动）特性的结合。我们从聚（五氟苯丙烯酸酯）（PPFPA）中阐述了多功能化的多孔胺反应性（PAR）聚合物膜。PAR 膜中的五氟苯酯基基于其对各种伯胺的高反应性，通过温和条件下的简单后修饰，促进了多种官能团的形成。我们将含胺的聚二甲基硅氧烷（胺-PDMS）和多巴胺引入到 PAR 膜中，分别导致抗污损硅油润滑剂的注入和杀菌银纳米颗粒（AgNPs）的形成。结果，基于 PAR 膜的润滑脂注入 AgNPs 掺入表面对水相和空气相大肠杆菌均表现出出色的抗菌效果，为开发有效的多模式抗生物污损表面开辟了新途径。
