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Growth patterns of influenza virus in cultures of ferret organs.雪貂器官培养物中流感病毒的生长模式。
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The localization of influenza virus: minimal infectious dose determinations and single cycle kinetic studies on organ cultures of respiratory and other ferret tissues.流感病毒的定位：呼吸道及其他雪貂组织器官培养物的最小感染剂量测定和单循环动力学研究
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T-cell-mediated immunopathology in viral infections.病毒感染中的T细胞介导的免疫病理学。
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Antibody responses to antigenic determinants of influenza virus hemagglutinin. I. Thymus dependence of antibody formation and thymus independence of immunological memory.针对流感病毒血凝素抗原决定簇的抗体反应。I. 抗体形成的胸腺依赖性及免疫记忆的胸腺非依赖性
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病毒感染性在诱导流感病毒特异性细胞毒性T细胞中的作用。

Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.

作者信息

Braciale T J, Yap K L

出版信息

J Exp Med. 1978 Apr 1;147(4):1236-52. doi: 10.1084/jem.147.4.1236.

DOI:10.1084/jem.147.4.1236
PMID:306410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184234/
Abstract

This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T-cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus-specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.

摘要

本报告研究了诱导流感病毒特异性细胞毒性T细胞时对感染性病毒的需求。发现感染性流感病毒在体内诱导原发性和继发性细胞毒性T细胞反应方面效率极高。然而，灭活的流感病毒即使在免疫剂量比感染性病毒的最小刺激剂量高10(5)-10(6)倍时，也未能在体内刺激可检测到的细胞毒性T细胞反应。同样，灭活病毒在体外也未能使靶细胞对T细胞介导的裂解敏感，但能在体外刺激致敏细胞产生特异性细胞毒性反应。根据这些观察结果以及其他研究者的观察结果，讨论了诱导病毒特异性细胞毒性T细胞反应的可能需求。