病毒感染性在诱导流感病毒特异性细胞毒性T细胞中的作用。
Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells.
作者信息
Braciale T J, Yap K L
出版信息
J Exp Med. 1978 Apr 1;147(4):1236-52. doi: 10.1084/jem.147.4.1236.
Abstract
This report examines the requirement for infectious virus in the induction of influenza virus-specific cytotoxic T cells. Infectious influenza virus was found to be highly efficient at generating both primary and secondary cytotoxic T-cell response in vivo. Inactivated influenza virus however, failed to stimulate a detectable cytotoxic T-cell response in vivo even at immunizing doses 10(5)-10(6)-fold higher than the minimum stimulatory dose of infectious virus. Likewise inactivated virus failed to sensitize target cells for T cell-mediated lysis in vitro but could stimulate a specific cytotoxic response from primed cells in vitro. Possible requirements for the induction of virus-specific cytotoxic T-cell responses are discussed in light of these observations and those of other investigators.
摘要
本报告研究了诱导流感病毒特异性细胞毒性T细胞时对感染性病毒的需求。发现感染性流感病毒在体内诱导原发性和继发性细胞毒性T细胞反应方面效率极高。然而，灭活的流感病毒即使在免疫剂量比感染性病毒的最小刺激剂量高10(5)-10(6)倍时，也未能在体内刺激可检测到的细胞毒性T细胞反应。同样，灭活病毒在体外也未能使靶细胞对T细胞介导的裂解敏感，但能在体外刺激致敏细胞产生特异性细胞毒性反应。根据这些观察结果以及其他研究者的观察结果，讨论了诱导病毒特异性细胞毒性T细胞反应的可能需求。
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