Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China; Departments of Environmental Health Sciences and Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY 12144, USA.
Environ Int. 2019 Mar;124:130-138. doi: 10.1016/j.envint.2019.01.006. Epub 2019 Jan 11.
Previous investigations on the associations of polyfluoroalkyl substances (PFASs) with overweight/obesity are mixed. Moreover, little information has been reported about the association between isomers of PFASs with body mass index (BMI), waist circumference (WC) or overweight. To address this shortcoming in the literature, we conducted a study involving 1612 Chinese adults (1204 men and 408 women), ages 22-96 years old, from Shenyang, China, to analyze serum isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other PFASs. Height, weight and WC were measured by a standardized protocol of WHO. Results indicated that increased serum concentrations of all (both branched and linear) isomers of PFASs were associated with a higher prevalence of overweight, and these associations were more pronounced in women. The adjusted odds ratios (ORs) from logistic regression analyses among women were 1.45 (95% confidence interval [CI]: 1.06, 1.99) for linear PFOS isomers, 1.33 (95% CI: 1.00, 1.77) for branched PFOS isomers, 1.39 (95% CI: 1.06, 1.81) for 3 + 4 + 5m PFOS, 1.54 (95% CI: 1.08, 2.21) for linear PFOA isomers, and 1.62 (95% CI: 1.05, 2.51) for branched PFOA isomers, respectively. Associations with increased WC were yielded a similar pattern. Linear regression models also showed positive associations between PFASs and BMI or WC. In conclusion, this study suggests that PFASs and their isomers are positively associated with overweight or increased WC, and the associations are stronger in women. Furthermore, PFOA and its isomers displayed the most robust obesogenic associations.
先前关于多氟烷基物质（PFASs）与超重/肥胖之间关联的研究结果不一。此外，关于 PFASs 异构体与体重指数（BMI）、腰围（WC）或超重之间的关联，鲜有报道。为了弥补文献中的这一不足，我们在中国沈阳开展了一项涉及 1612 名成年人（1204 名男性和 408 名女性）的研究，年龄在 22-96 岁之间，分析了血清中全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）和其他 PFASs 的异构体。身高、体重和 WC 均按照世界卫生组织的标准化方案进行测量。结果表明，所有（直链和支链）PFASs 异构体血清浓度的增加与超重的患病率升高有关，且这些关联在女性中更为明显。多因素逻辑回归分析显示，女性中直链 PFOS 异构体的比值比（OR）为 1.45（95%置信区间[CI]：1.06，1.99），支链 PFOS 异构体为 1.33（95%CI：1.00，1.77），3+4+5m PFOS 为 1.39（95%CI：1.06，1.81），直链 PFOA 异构体为 1.54（95%CI：1.08，2.21），支链 PFOA 异构体为 1.62（95%CI：1.05，2.51）。与 WC 增加相关的结果也呈现出相似的模式。线性回归模型还显示 PFASs 与 BMI 或 WC 之间存在正相关关系。总之，本研究表明，PFASs 及其异构体与超重或 WC 增加呈正相关，且在女性中关联更强。此外，PFOA 及其异构体与肥胖的关联最为显著。
