Burdeau Jordan A, Stephenson Briana J K, Aris Izzuddin M, Mahalingaiah Shruthi, Chavarro Jorge E, Preston Emma V, Hivert Marie-France, Oken Emily, Calafat Antonia M, Rifas-Shiman Sheryl L, Zota Ami R, James-Todd Tamarra
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Obesity (Silver Spring). 2025 Apr;33(4):807-816. doi: 10.1002/oby.24250. Epub 2025 Mar 12.
The objective of this study was to evaluate associations of early-pregnancy plasma per- and polyfluoroalkyl substances (PFAS) with maternal post-pregnancy weight trajectory parameters.
We studied 1106 Project Viva participants with measures of early-pregnancy plasma concentrations of eight PFAS. We measured weight at in-person visits at 6 months and 3, 7, and 12 years after pregnancy and collected self-reported weight via annual questionnaires up to 17 years after pregnancy. Weight trajectory parameters were estimated via the Superimposition by Translation and Rotation model. We assessed individual and joint effects of PFAS with trajectory parameters using linear regression and Bayesian kernel machine regression (BKMR).
Perfluorooctane sulfonate (PFOS) concentrations were positively associated with weight trajectory magnitude in both linear regression (0.8 kg [95% CI: 0.1 to 1.4] per doubling of PFOS) and BKMR analyses (2.6 kg [95% CI: 1.4 to 3.8] per increase from 25th to 75th percentile of PFOS concentrations). Conversely, in BKMR analyses, perfluorononanoate was negatively associated with trajectory magnitude (-2.0 kg [95% CI: -2.9 to -1.1]). In stratified linear regression, older-aged participants had more pronounced positive associations of PFOS, perfluorooctanoate, and 2-(N-ethyl-perfluorooctane sulfonamido) acetate with weight trajectory velocity. No associations were observed with the overall PFAS mixture.
Select PFAS, assessed in pregnancy, may affect maternal weight trajectories spanning 17 years after pregnancy, especially for older-aged individuals.
本研究的目的是评估妊娠早期血浆全氟和多氟烷基物质（PFAS）与产后体重轨迹参数之间的关联。
我们对1106名参加Viva项目的参与者进行了研究，测量了他们妊娠早期血浆中8种PFAS的浓度。我们在产后6个月、3年、7年和12年的面对面访视中测量体重，并通过年度问卷收集产后长达17年的自我报告体重。体重轨迹参数通过平移和旋转叠加模型进行估计。我们使用线性回归和贝叶斯核机器回归（BKMR）评估PFAS对轨迹参数的个体和联合效应。
在线性回归（全氟辛烷磺酸每增加一倍，体重轨迹幅度增加0.8千克[95%置信区间：0.1至1.4]）和BKMR分析（全氟辛烷磺酸浓度从第25百分位数增加到第75百分位数，体重轨迹幅度增加2.6千克[95%置信区间：1.4至3.8]）中，全氟辛烷磺酸（PFOS）浓度与体重轨迹幅度呈正相关。相反，在BKMR分析中，全氟壬酸与轨迹幅度呈负相关（-2.0千克[95%置信区间：-2.9至-1.1]）。在分层线性回归中，年龄较大的参与者中，PFOS、全氟辛酸和2-（N-乙基-全氟辛烷磺酰胺基）乙酸与体重轨迹速度的正相关更为明显。未观察到与PFAS混合物总体的关联。
孕期评估的特定PFAS可能会影响产后长达17年的母亲体重轨迹，尤其是对年龄较大的个体。
