School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, 200032, China.
Department of Animal Science, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, R3T2N2, Canada.
Chemosphere. 2019 Apr;221:349-355. doi: 10.1016/j.chemosphere.2019.01.061. Epub 2019 Jan 9.
Laboratory studies have suggested that perfluoroalkyl substances (PFASs) could affect fetal growth by disrupting estrogen homeostasis, but there are limited data for human. For this, 424 mother-infant pairs were selected from a cohort established in Hebei Province of North China in 2013. Two typical PFASs, perfluorooctyl sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), and three typical estrogens, estrone (E), β-estradiol (E), and estriol (E), were measured in cord serum. After adjusted for important covariates, serum PFOS was positively related to E and E, but negatively related to E. Serum PFOA was positively related to serum E and negatively related to head circumference at birth. Serum E was negatively related to head circumference, body weight, and body length at birth and serum E was positively related to body weight. Serum E mediated the relationship between serum PFOS and body weight. There were sex-specific differences for the associations between PFOS/PFOA and estrogens/birth size. These findings suggested that exposure to PFASs could affect estrogen homeostasis and fetal growth during pregnancy and that estrogens might mediate the association between exposure to PFASs and fetal growth.
实验室研究表明，全氟烷基物质（PFAS）可能通过破坏雌激素平衡来影响胎儿生长，但人类的数据有限。为此，我们从 2013 年在中国华北河北省建立的队列中选择了 424 对母婴。在脐带血清中测量了两种典型的 PFAS，即全氟辛基磺酸（PFOS）和全氟辛酸（PFOA），以及三种典型的雌激素，雌酮（E）、β-雌二醇（E）和雌三醇（E）。在调整了重要协变量后，血清 PFOS 与 E 和 E 呈正相关，但与 E 呈负相关。血清 PFOA 与血清 E 呈正相关，与出生时头围呈负相关。血清 E 与出生时的头围、体重和体长呈负相关，而血清 E 与体重呈正相关。血清 E 介导了血清 PFOS 与体重之间的关系。PFOS/PFOA 与雌激素/出生体重之间的关联存在性别特异性差异。这些发现表明，PFASs 的暴露可能会在怀孕期间影响雌激素平衡和胎儿生长，而雌激素可能会介导 PFASs 暴露与胎儿生长之间的关联。
