Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
Chemosphere. 2013 Aug;92(7):843-50. doi: 10.1016/j.chemosphere.2013.04.038. Epub 2013 May 18.
Perfluoroalkyl substances (PFASs) can cross the placenta, enter fetal circulation, and were found to correlate with adverse fetal growth. However, determinants of cord blood PFASs are not fully characterized. The study aimed to explore the association between PFASs and neonatal-maternal factors within a Taiwanese birth cohort. We selected subjects from Taiwan Birth Panel Study, which enrolled 486 infant-mother pairs in 2004-2005. We collected cord blood and analyzed perfluorooctanoic acid (PFOA), perfluorooctanyl sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) using a simple protein precipitation and an ultra-high performance liquid chromatography/tandem mass spectrometry. We retrieved information pertaining to maternal socio-demographics, lifestyle- and dietary-related factors through structured questionnaires during the postpartum hospital stay. A total of 439 subjects, with 90% response rate, have completed serum analysis and questionnaire survey. The median concentrations for PFOA, PFOS, PFNA, and PFUA in cord blood were 1.86, 5.67, 3.00, and 13.5ngmL(-1), respectively. After adjusting for potential confounders, multiple linear regression models revealed that log10-PFOA was positively associated with maternal age (β=0.011) and negatively associated with multiparity (β=-0.044). Log10-PFOS was negatively correlated with birth weight (β=-0.011) and higher maternal education (senior high school: β=-0.067; university: β=-0.088). Log10-PFUA tended to negatively associate with gender, male infants (β=-0.075), and using cosmetics during pregnancy (β=-0.065). Interestingly, presence of cockroaches in the home was positively associated with log10-PFOA (β=0.041) and 1og10-PFNA (β=0.123). In conclusion, this study demonstrated several factors to correlate with cord blood PFASs and further investigation are still needed for confirmation of exposure routes.
全氟烷基物质（PFAS）可以穿过胎盘，进入胎儿循环，并被发现与胎儿生长不良相关。然而，脐带血中 PFAS 的决定因素尚未完全确定。本研究旨在探索台湾出生队列中 PFAS 与母婴因素之间的关联。我们从台湾出生队列研究中选择了 486 对母婴，在 2004-2005 年期间进行了招募。我们采集了脐带血，并使用简单的蛋白质沉淀和超高效液相色谱/串联质谱法分析了全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）和全氟癸酸（PFDA）。我们在产后住院期间通过结构化问卷收集了与母亲社会人口统计学、生活方式和饮食相关因素的信息。共有 439 名参与者，应答率为 90%，完成了血清分析和问卷调查。脐带血中 PFOA、PFOS、PFNA 和 PFDA 的中位数浓度分别为 1.86、5.67、3.00 和 13.5ng/mL。在调整了潜在混杂因素后，多元线性回归模型显示，log10-PFOA 与母亲年龄呈正相关（β=0.011），与多胎产呈负相关（β=-0.044）。log10-PFOS 与出生体重呈负相关（β=-0.011），与母亲受教育程度较高呈负相关（高中：β=-0.067；大学：β=-0.088）。log10-PFUA 与性别、男婴（β=-0.075）和孕期使用化妆品（β=-0.065）呈负相关趋势。有趣的是，家中有蟑螂与 log10-PFOA（β=0.041）和 log10-PFNA（β=0.123）呈正相关。综上所述，本研究表明了一些因素与脐带血 PFAS 相关，需要进一步研究以确认暴露途径。
