Siddiqui Khalid, George Teena P, Nawaz Shaik Sarfaraz, Yaslam Maram, Almogbel Ebtehal, Al-Rubeaan Khalid
Strategic Center for Diabetes Research, King Saud University, Riyadh, Saudi Arabia.
University Diabetes Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Diabetes Metab Syndr. 2019 Jan-Feb;13(1):548-552. doi: 10.1016/j.dsx.2018.11.023. Epub 2018 Nov 3.
The aim of this study was to investigate the role of elevated glycated LDL (low-density lipoprotein) in the progression of diabetic kidney disease among type 2 diabetes (T2D) subjects.
This case-control observational study is a part of Saudi Diabetes Kidney Disease (SAUDI-DKD) study conducted during the period from April 2014 to June 2015. This study cohort is divided into two groups; the first group was T2D patients without diabetic nephropathy (DN) (n = 24) and the second group was T2D with DN (n = 45). Serum glycated LDL levels were determined by ELISA. Pearson's correlation analysis was performed, and the diagnostic accuracy was assessed using the area under the ROC curve.
There was a threefold increase of serum glycated LDL level among diabetic subjects when compared with non-diabetic subjects and this level progressively increased with the progression of DN. The glycated LDL was found to have a significant diagnostic accuracy with AUC of 0.685 and 0.775 for cases with microalbuminuria and macroalbuminuria respectively.
The glycated LDL could play a significant role in predicting diabetic patients who are susceptible to develop DN among T2D patients.
本研究旨在探讨糖化低密度脂蛋白（LDL）升高在2型糖尿病（T2D）患者糖尿病肾病进展中的作用。
本病例对照观察性研究是2014年4月至2015年6月期间进行的沙特糖尿病肾病（SAUDI-DKD）研究的一部分。本研究队列分为两组；第一组为无糖尿病肾病（DN）的T2D患者（n = 24），第二组为患有DN的T2D患者（n = 45）。采用酶联免疫吸附测定法（ELISA）测定血清糖化LDL水平。进行Pearson相关性分析，并使用ROC曲线下面积评估诊断准确性。
与非糖尿病受试者相比，糖尿病受试者血清糖化LDL水平增加了两倍，且该水平随DN的进展而逐渐升高。发现糖化LDL具有显著的诊断准确性，微蛋白尿和大量蛋白尿病例的AUC分别为0.685和0.775。
糖化LDL在预测T2D患者中易发生DN的糖尿病患者方面可能发挥重要作用。
