Izadi Morteza, Kheirjou Ramin, Mohammadpour Roya, Aliyoldashi Mohammad Hassan, Moghadam Saeedreza Jamali, Khorvash Farzin, Jafari Nematollah Jonaidi, Shirvani Shahram, Khalili Nahid
Ozone Therapy Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Ozone Therapy Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Diabetes Metab Syndr. 2019 Jan-Feb;13(1):822-825. doi: 10.1016/j.dsx.2018.11.060. Epub 2018 Dec 1.
Diabetic foot ulcer is one of the common complications of diabetes disease that is costly and difficult to treat. This problem can lead to morbidity and even mortality. Ozone is a gas that can optimize cellular metabolism and, because of its antioxidant and antibacterial effects, can help the better healing of diabetic foot ulcer.
Two hundred patients, aged 18-85 with diabetic foot ulcers ranging from grade 1 to 4 according to Wagner classification in two groups were studied. Group 1 was treated by full ozone therapy besides the standard regular DFU treatment while group two just was received routine diabetic foot care. Wound size, wound grade, healing time, Fasting blood sugar and inflammatory biomarker before and after treatment were checked.
All patients have had complete wound closure in the ozone group. The mean age of the patients included in the results was 59.03 ± 12.593 and 53.5 ± 10.212 for ozone group and control group. The baseline average surface area of ulcers was 13.41 ± 14.092 cm (range 1-70 cm) in ozone group and 12.72 ± 0.911 (range 1_64 cm) in the control group. Average healing time was 69.44 ± 36.055 days (range 15-180 days), which is significantly lower than the median healing time measured in the control group and some previous studies.
Our study results support the efficacy of ozone therapy especially in its comprehensive use in DFU healing and reduction in the chances of infection and amputation.
糖尿病足溃疡是糖尿病常见的并发症之一，治疗成本高且难度大。这个问题可能导致发病甚至死亡。臭氧是一种能优化细胞代谢的气体，因其抗氧化和抗菌作用，有助于糖尿病足溃疡更好地愈合。
对两组年龄在18 - 85岁、根据瓦格纳分类法溃疡分级为1至4级的糖尿病足溃疡患者进行研究。第1组除接受标准的常规糖尿病足溃疡治疗外，还接受全臭氧治疗，而第2组仅接受常规糖尿病足护理。检查治疗前后的伤口大小、伤口分级、愈合时间、空腹血糖和炎症生物标志物。
臭氧组所有患者伤口均完全愈合。结果纳入患者的平均年龄，臭氧组为59.03 ± 12.59³，对照组为53.5 ± 10.21²。臭氧组溃疡的基线平均表面积为13.41 ± 14.09² cm（范围1 - 70 cm），对照组为12.72 ± 0.91¹（范围1 - 64 cm）。平均愈合时间为69.44 ± 36.05⁵天（范围15 - 180天），显著低于对照组及之前一些研究测得的中位愈合时间。
我们的研究结果支持臭氧治疗的疗效，尤其是其在糖尿病足溃疡愈合中的综合应用以及降低感染和截肢几率方面的疗效。
