Division of Oncology, S. Orsola-Malpighi Hospital, Bologna 40138, Italy.
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona 60126, Italy.
Cells. 2019 Jan 11;8(1):43. doi: 10.3390/cells8010043.
Management of metastatic or advanced prostate cancer has acquired several therapeutic approaches that have drastically changed the course of the disease. In particular due to the high sensitivity of prostate cancer cells to hormone depletion, several agents able to inhibit hormone production or binding to nuclear receptor have been evaluated and adopted in clinical practice. However, despite several hormonal treatments being available nowadays for the management of advanced or metastatic prostate cancer, the natural history of the disease leads inexorably to the development of resistance to hormone inhibition. Findings regarding the mechanisms that drive this process are of particular and increasing interest as these are potentially related to the identification of new targetable pathways and to the development of new drugs able to improve our patients' clinical outcomes.
转移性或晚期前列腺癌的治疗已经取得了一些进展,这些治疗方法极大地改变了疾病的进程。特别是由于前列腺癌细胞对激素耗竭非常敏感,因此已经评估了几种能够抑制激素产生或与核受体结合的药物,并在临床实践中得到了应用。然而,尽管目前有几种激素治疗方法可用于治疗晚期或转移性前列腺癌,但该疾病的自然病程不可避免地导致对激素抑制的耐药性的产生。关于驱动这一过程的机制的研究结果具有特别重要的意义,因为这些机制可能与确定新的可靶向途径和开发能够改善患者临床结局的新药有关。