Choi Il Ju
Center for Gastric Cancer, National Cancer Center, Goyang, Korea.
Korean J Gastroenterol. 2018 Nov 25;72(5):245-251. doi: 10.4166/kjg.2018.72.5.245.
Gastric cancer is the most common cancer in Korea and the fifth most common cancer globally. infection is considered the main etiologic agent for gastric cancer development. Most regional guidelines for treatment recommend treating the organism to prevent gastric cancer in the high-risk group. However, evidence that such a strategy can also be applied to the general population, especially in terms of the preventive effect and safety, has not been adequately presented yet. Although a meta-analysis in the general population suggested effectiveness in decreasing gastric cancer incidence, individual studies should be critically reviewed to evaluate the soundness of the evidence. Recently published, long-term, Korean studies on metachronous gastric cancer prevention ended the controversies from previous short-term studies and confirmed the effectiveness. Currently, further prospective, large, randomized studies are ongoing in the general population and will provide more definitive, high-level evidence on this gastric cancer prevention strategy in the next decade.
胃癌是韩国最常见的癌症，也是全球第五大常见癌症。感染被认为是胃癌发生的主要病因。大多数地区的治疗指南建议对高危人群进行除菌治疗以预防胃癌。然而，尚无充分证据表明这种策略也适用于普通人群，尤其是在预防效果和安全性方面。尽管一项针对普通人群的荟萃分析表明降低胃癌发病率有效果，但仍应审慎评估个体研究证据的可靠性。最近发表的韩国关于异时性胃癌预防的长期研究结束了此前短期研究的争议，并证实了其有效性。目前，普通人群中正在进行进一步的前瞻性、大规模、随机研究，未来十年将为这种胃癌预防策略提供更确凿、更高级别的证据。
