Cervantes Jessica, Rosen Alyx, Cho Jeong Hee
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Skin Appendage Disord. 2018 Nov;5(1):52-55. doi: 10.1159/000488723. Epub 2018 Jun 5.
Extramammary Paget disease is a rare, slow-growing intraepithelial neoplasm of the skin or its underlying appendages. It more commonly affects the apocrine glands of the axilla, vulva, perianal region, scrotum, and/or penis. It often presents as a well-demarcated, thickened, erythematous, or gray-white scaly plaque with indolent growth that may become ulcerated, crusted, papillomatous, or eczematous over time. Pruritus, pain, and burning sensations are common symptoms; however, they are not appreciated by all patients. Many patients are erroneously treated for eczema for months to years before a proper diagnosis is reached. Patients presenting with chronic genital or perineal dermatitis or skin lesions that have been unresponsive to topical therapy should be biopsied for definitive diagnosis.
乳腺外佩吉特病是一种罕见的、生长缓慢的皮肤或其附属器上皮内肿瘤。它更常累及腋窝、外阴、肛周区域、阴囊和/或阴茎的顶泌汗腺。它通常表现为边界清晰、增厚、红斑或灰白色鳞屑斑块，生长缓慢，随着时间的推移可能会出现溃疡、结痂、乳头瘤样或湿疹样改变。瘙痒、疼痛和烧灼感是常见症状；然而，并非所有患者都会出现这些症状。许多患者在得到正确诊断之前，被误诊为湿疹长达数月至数年之久。出现慢性生殖器或会阴皮炎或对局部治疗无反应的皮肤病变的患者，应进行活检以明确诊断。
