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用于研究不可分型流感嗜血杆菌中由相位可变DNA甲基转移酶介导的基因表达变化的高深度RNA测序数据集。

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

作者信息

Atack John M, Bakaletz Lauren O, Jennings Michael P

机构信息

Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.

出版信息

Microbiol Resour Announc. 2019 Jan 10;8(2). doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.

DOI:10.1128/MRA.01500-18
PMID:30643897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6328670/
Abstract

Nontypeable Haemophilus influenzae (NTHi) is a major bacterial pathogen that causes multiple infections. We report high-depth-coverage RNA-Seq data from three NTHi strains, each of which encodes a different phase-variable methyltransferase. Major gene expression differences occur, commensurate with phase variation, and data will serve as an important resource for future studies.

摘要

不可分型流感嗜血杆菌(NTHi)是一种可引发多种感染的主要细菌病原体。我们报告了来自三株NTHi菌株的高深度覆盖RNA测序数据,每株菌株都编码一种不同的相变甲基转移酶。主要基因表达差异与相变相关,这些数据将成为未来研究的重要资源。

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本文引用的文献

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Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.细菌病原体的相变:甲基化组学为老对手带来新认识
Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13.
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The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.非典型流感嗜血杆菌 ModA2 相变异体调控对氧化应激和人中性粒细胞杀伤的抗性。
Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.
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The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.细菌病原体的多变性质:相变调控子与疫苗开发
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ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.不可分型流感嗜血杆菌中的ModA2相变开关增加了实验性中耳炎的严重程度。
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Invasive Disease Caused by Nontypeable Haemophilus influenzae.非分型流感嗜血杆菌引起的侵袭性疾病
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A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.一种双相表观遗传开关控制非分型流感嗜血杆菌的免疫逃逸、毒力和生态位适应。
Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.
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