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2
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引用本文的文献

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Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions.从慢性阻塞性肺疾病患者中分离到的非分型流感嗜血杆菌含有新的相变异型 modA 甲基转移酶等位基因,这些基因控制着相变异。
Sci Rep. 2019 Nov 4;9(1):15963. doi: 10.1038/s41598-019-52429-6.

本文引用的文献

1
High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.用于研究不可分型流感嗜血杆菌中由相位可变DNA甲基转移酶介导的基因表达变化的高深度RNA测序数据集。
Microbiol Resour Announc. 2019 Jan 10;8(2). doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.
2
Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.两株来自慢性阻塞性肺疾病患者痰液的携带新等位基因的不可分型流感嗜血杆菌菌株的封闭全基因组序列
Microbiol Resour Announc. 2018 Jul 19;7(2). doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.
3
genome evolution during persistence in the human airways in chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者气道内持续存在期间的基因组进化。
Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3256-E3265. doi: 10.1073/pnas.1719654115. Epub 2018 Mar 19.
4
Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.细菌病原体的相变:甲基化组学为老对手带来新认识
Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13.
5
The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.非典型流感嗜血杆菌 ModA2 相变异体调控对氧化应激和人中性粒细胞杀伤的抗性。
Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.
6
The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.细菌病原体的多变性质:相变调控子与疫苗开发
Front Immunol. 2016 Dec 12;7:586. doi: 10.3389/fimmu.2016.00586. eCollection 2016.
7
ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.不可分型流感嗜血杆菌中的ModA2相变开关增加了实验性中耳炎的严重程度。
J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.
8
A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.一种双相表观遗传开关控制非分型流感嗜血杆菌的免疫逃逸、毒力和生态位适应。
Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.
9
Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae.相变异关联的 modA 基因中致病性奈瑟氏菌和流感嗜血杆菌 DNA 识别域多样性的起源。
PLoS One. 2012;7(3):e32337. doi: 10.1371/journal.pone.0032337. Epub 2012 Mar 23.
10
Infection in the pathogenesis and course of chronic obstructive pulmonary disease.感染在慢性阻塞性肺疾病的发病机制及病程中的作用
N Engl J Med. 2008 Nov 27;359(22):2355-65. doi: 10.1056/NEJMra0800353.

用于确定慢性阻塞性肺疾病患者分离的不可分型流感嗜血杆菌菌株中由相变DNA甲基转移酶介导的基因表达变化的转录组测序数据集。

Transcriptome Sequencing Data Sets for Determining Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae Strains Isolated from Patients with Chronic Obstructive Pulmonary Disease.

作者信息

Atack John M, Murphy Timothy F, Pettigrew Melinda M, Seib Kate L, Jennings Michael P

机构信息

Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

Clinical and Translational Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.

出版信息

Microbiol Resour Announc. 2019 Jul 18;8(29):e00526-19. doi: 10.1128/MRA.00526-19.

DOI:10.1128/MRA.00526-19
PMID:31320413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6639615/
Abstract

Nontypeable (NTHi) is a major bacterial cause of exacerbations in chronic obstructive pulmonary disease (COPD). Here, we report high-depth coverage transcriptome sequencing (RNA-seq) data from two NTHi strains, each encoding a different phase-variable methyltransferase. phase variation results in gene expression differences. These data will serve as an important resource for future studies.

摘要

不可分型流感嗜血杆菌(NTHi)是慢性阻塞性肺疾病(COPD)病情加重的主要细菌病因。在此,我们报告了来自两株NTHi菌株的高深度覆盖转录组测序(RNA测序)数据,每株菌株编码一种不同的相位可变甲基转移酶。相位变异导致基因表达差异。这些数据将成为未来研究的重要资源。