Department of Neuroscience and Organs of Sense, Orthopaedics Section, University of Bari Aldo Moro, Bari, Italy.
National Center For Chemicals, Cosmetic Products And Consumer Protection, National Institute of Health, Rome, Italy.
J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6 Suppl. 1):23-28.
Clinical biophysics investigates the relationship between non-ionizing physical energy and the human body. Although several types of electrical stimulation devices have received US FDA approval for orthopaedic application, the use of Pulsed Electromagnetic Field (PEMFs) play a central role in joint biophysics. This narrative review aims to summarize the current evidences on the efficacy of PEMF-therapy in the treatment of knee articular diseases. Preclinical studies have assessed the effects of PEMFs on chondrocytes, synoviocytes, articular cartilage explants and animal models, showing positive effects of PEMF-therapy on cells proliferation, extracellular matrix (ECM) production, chondrocytes apoptosis and inflammatory cytokines down-regulation. Currently, PEMF-therapy is a valid option in the conservative management of several knee articular diseases, including early OA, patellofemoral pain syndrome and SONK. PEMFs could be also used as an adjunct after an arthroscopic knee procedure or TKA implantation, in order to control the joint post-operative inflammatory state.
临床生物物理研究非电离物理能量与人体之间的关系。尽管有几种类型的电刺激设备已获得美国 FDA 批准用于骨科应用，但脉冲电磁场 (PEMF) 在关节生物物理学中起着核心作用。本叙述性综述旨在总结 PEMF 治疗膝关节疾病的疗效的现有证据。临床前研究评估了 PEMF 对软骨细胞、滑膜细胞、关节软骨外植体和动物模型的影响，显示 PEMF 治疗对细胞增殖、细胞外基质 (ECM) 产生、软骨细胞凋亡和炎症细胞因子下调有积极作用。目前，PEMF 治疗是几种膝关节疾病保守治疗的有效选择，包括早期 OA、髌股疼痛综合征和 SONK。PEMF 也可以用作关节镜膝关节手术后或 TKA 植入后的辅助治疗，以控制关节术后炎症状态。
