School of Medicine, University of Bari "Aldo Moro"- AOU Consorziale "Policlinico" - Department of Basic Medical Sciences, Neuroscience and Sense Organs, Orthopaedic & Trauma Unit, Bari, Italy.
National Centre for Chemicals, Cosmetic Products and Consumer Protection, National Institute of Health, Rome, Italy.
J Biol Regul Homeost Agents. 2020 Sep-Oct;34(5 Suppl. 1):131-135. IORS Special Issue on Orthopedics.
Clinical biophysics investigates the relationship between non-ionizing physical energy and the human body. This narrative review aims to summarize the current evidence on the efficacy of PEMF-therapy in the promotion of fracture healing. The effectiveness of PEMFs has been deeply investigated in preclinical in vitro ed in vivo studies and level-I clinical studies. All these studies depicted only PEMF-devices with specific physical wave features - i.e. pulse shape, frequency and amplitude- could significantly promote bone repair. Moreover, the dose-response relationship was also defined in preclinical studies, thus providing the minimum exposure time needed in PEMF-therapy. PEMFs are currently employed in the management several bone injuries, including acute fractures at non-union risk, non-unions, osteotomies, stress fractures and osteonecrosis. Moreover, several ongoing studies are investigating the effectiveness of PEMFs on emerging clinical conditions, thus the indications to PEMF-therapy could potentially raise in future years.
临床生物物理研究非电离物理能量与人体之间的关系。本综述旨在总结电磁场治疗促进骨折愈合疗效的现有证据。电磁场的有效性已在临床前的体外和体内研究以及一级临床研究中进行了深入研究。所有这些研究都表明，只有具有特定物理波特征的电磁场设备——即脉冲形状、频率和幅度——才能显著促进骨修复。此外，在临床前研究中还确定了剂量反应关系，从而提供了电磁场治疗所需的最短暴露时间。电磁场目前用于治疗多种骨损伤，包括有非愈合风险的急性骨折、骨不连、截骨术、应力性骨折和骨坏死。此外，目前正在进行多项研究，以调查电磁场对新兴临床疾病的有效性，因此，电磁场治疗的适应证在未来几年可能会增加。
