Orthopaedic Clinic, University of Florence.
Operative Unit of Orthopaedics and Traumatology, Fond. IRCCS Policlinico S.an Matteo, Pavia.
J Biol Regul Homeost Agents. 2018 Nov-Dec;32(6 Suppl. 1):173-179.
Bone turnover is a complex set of different molecules pathways and it is strictly connected with bone vasculature. It includes every bone process concerning bone modelling and remodelling such us skeletal growth and healing process. A fundamental component of this bone architecture is played by the endothelium, that acts in a paracrine fashion on other bone stromal cells via humoral factors, growth factors and chemokines/cytokines. The alteration of those biochemical interactions between endothelium, vasculature and bone tissue may cause various pathological manifestations. Understanding the bases of the interaction between those different pathways could provide novel therapeutic strate¬gies for bone disease. The Authors present an updated overview of the most common communication biomolecules between bone cells and endothelium and their interactions both in healthy and pathological conditions. Furthermore, focusing on gene and related therapies, possible future therapeutic strategies for bone vasculature/metabolic diseases are presented.
骨转换是一组复杂的不同分子途径，它与骨血管密切相关。它包括与骨建模和重塑有关的所有骨骼过程，例如骨骼生长和愈合过程。这种骨结构的一个基本组成部分是内皮细胞，它通过体液因子、生长因子和趋化因子/细胞因子以旁分泌的方式作用于其他骨基质细胞。内皮细胞、血管和骨组织之间这些生化相互作用的改变可能导致各种病理表现。了解这些不同途径之间相互作用的基础可以为骨疾病提供新的治疗策略。作者介绍了骨细胞和内皮细胞之间最常见的通讯生物分子及其在健康和病理条件下相互作用的最新综述。此外，作者还重点介绍了基因和相关治疗方法，提出了骨血管/代谢疾病的未来可能治疗策略。
