Stogiannou D, Protopapas Adonis, Protopapas Andreas, Tziomalos K
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
Acta Gastroenterol Belg. 2018 Oct-Dec;81(4):520-524.
Propofol is a sedative agent commonly used for sedation in gastrointestinal endoscopy. Its pharmacologic properties render propofol an almost ideal drug to achieve and maintain the targeted level of sedation in even complex gastrointestinal procedures. When compared with other sedative agents, propofol is associated with better patient and endoscopist satisfaction and shorter recovery times. Furthermore, propofol can be combined with other sedatives to reduce the total dosage required to achieve the targeted sedation. Its safety is demonstrated by multiple studies, in which adverse events occurred very rarely. Nevertheless, the use of propofol by non-anesthesiologists is illegal in many countries and in those permitted, a structured curriculum with clinical training must first be successfully completed. However, various studies have shown that non-anesthesiologist administration of propofol is comparable in efficacy and safety to administration by an anesthesiologist and more cost-effective. The results of numerous studies indicate that propofol is superior in many aspects compared with traditional sedative agents.
丙泊酚是一种常用于胃肠内镜检查镇静的镇静剂。其药理特性使丙泊酚成为一种几乎理想的药物，即使在复杂的胃肠手术中也能达到并维持目标镇静水平。与其他镇静剂相比，丙泊酚能提高患者和内镜医师的满意度，且恢复时间更短。此外，丙泊酚可与其他镇静剂联合使用，以减少达到目标镇静所需的总剂量。多项研究证明了其安全性，其中不良事件极少发生。然而，在许多国家，非麻醉医生使用丙泊酚是非法的，而在允许使用的国家，必须首先成功完成具有临床培训的结构化课程。不过，各种研究表明，非麻醉医生使用丙泊酚在疗效和安全性方面与麻醉医生使用相当，且成本效益更高。大量研究结果表明，丙泊酚在许多方面优于传统镇静剂。
