Nam Su Youn, Park Bum Joon, Cho Yeong-Ah, Ryu Kum Hei
Department of Gastroenterology, Center for Gastric Cancer, Kyungpook National University Hospital, Buk-gu, Daegu, Korea.
Department of Internal Medicine, Center for Cancer Prevention & Detection, National Cancer Center, Goyang, Gyeonggi-do, Korea.
J Neurogastroenterol Motil. 2019 Jan 31;25(1):82-90. doi: 10.5056/jnm18114.
BACKGROUND/AIMS: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD.
A total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. To evaluate the effect of dietary micronutrients on NERD or erosive esophagitis, adjusted regression analysis with odds ratio (OR) and 95% confidence interval (CI) was used. In addition, we performed gender-specific analysis.
Prevalence of NERD and erosive esophagitis was 6.8% and 11.2% in men and 9.1% and 2.4% in women. In adjusted analysis, high intake of vitamin A (OR, 0.78; 95% CI, 0.64-0.96), retinol (OR, 0.73; 95% CI, 0.59-0.90), vitamin B2 (OR, 0.68; 95% CI, 0.54-0.87), vitamin B6 (OR, 0.75; 95% CI, 0.58-0.96), folic acid (OR, 0.77; 95% CI, 0.62-0.96), calcium (OR, 0.66; 95% CI, 0.53-0.82), and iron (OR, 0.68; 95% CI, 0.53-0.87) had an inverse association with NERD. However, erosive esophagitis has no relationship with micronutrients except vitamin C (OR, 0.78; 95% CI, 0.62-0.98). High dietary intake of calcium reduced the risk of NERD in men and high dietary intake of many micronutrients reduced NERD in women.
While many dietary micronutrients reduced NERD, they had no effect on erosive esophagitis. The effect of micronutrient on NERD was more prominent in women than men.
背景/目的：膳食微量营养素对非糜烂性反流病（NERD）和反流性食管炎的影响尚不清楚。我们旨在评估微量营养素对糜烂性食管炎和NERD的性别特异性影响。
2004年至2008年，共有11690名参与者接受了内镜检查，并完成了为期3天的饮食摄入量记录以及反流症状问卷调查。为评估膳食微量营养素对NERD或糜烂性食管炎的影响，采用了调整后的回归分析，计算比值比（OR）和95%置信区间（CI）。此外，我们还进行了性别特异性分析。
男性NERD和糜烂性食管炎的患病率分别为6.8%和11.2%，女性分别为9.1%和2.4%。在调整分析中，高摄入维生素A（OR，0.78；95%CI，0.64 - 0.96）、视黄醇（OR，0.73；95%CI，0.59 - 0.90）、维生素B2（OR，0.68；95%CI，0.54 - 0.87）、维生素B6（OR，0.75；95%CI，0.58 - 0.96）、叶酸（OR，0.77；95%CI，0.62 - 0.96）、钙（OR，0.66；95%CI，0.53 - 0.82）和铁（OR，0.68；95%CI，0.53 - 0.
