Cordoba Díaz Damian, Losa Iglesias Marta Elena, Becerro de Bengoa Vallejo Ricardo, Cordoba Diaz Manuel
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Facultad Ciencias de la Salud, Universidad Rey Juan Carlos, 28933 Madrid, Spain.
Pharmaceutics. 2019 Jan 14;11(1):29. doi: 10.3390/pharmaceutics11010029.
Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3⁻4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition.
甲癣是一种指甲真菌感染，由于人类指甲具有不透性，这种感染很普遍且难以治疗。局部应用的抗真菌剂无法穿透该结构，治疗方案通常采用有伴随副作用的全身用抗真菌药。最近的一项临床研究表明，使用智能指甲钻对指甲进行机械打孔可能是解决这一问题的一种方法。在这项工作中，提出了一种抗真菌剂经指甲递送的体外模型，该模型利用真实的指甲组织和在线流动系统。该系统用于测量环吡酮的经指甲递送情况，并确定在42天后指甲打孔使药物递送提高了3至4倍。这项研究支持了指甲打孔应被接受为甲癣预处理方法的观点，并提供了一种评估旨在对抗这种疾病的新药或制剂的方法。
