Sadoun D, Komajda M, Drobinski G, Thomas D, Vanetti A, Grosgogeat Y
Service de Cardiologie, Hôpital de la Salpêtrière, Paris.
Ann Cardiol Angeiol (Paris). 1988 Jul-Sep;37(7):365-9.
We are reporting the case of a 63 year-old woman presenting an early thrombosis of a mechanical aortic Saint-Jude prosthesis, on the 21st post-operative day, following an insufficient anti-coagulant treatment and discovered by the presence of a well tolerated murmur of aortic insufficiency. The treatment consisted in fibrinolysis using urokinase, administered intravenously at a dose of 4,400 IU/kg/hour, for 12 hours. The clinical, ultrasound and radiocinematographic control performed on the 75th day, were normal; the patient, at that time being treated with anti-vitamin K and platelets anti-aggregates. No complication was observed. This case demonstrates the advantages of fibrinolytic treatments in early thrombosis following insertion of a valvular prosthesis.
我们报告了一名63岁女性的病例，该患者在术后第21天出现机械主动脉圣犹达瓣膜早期血栓形成，原因是抗凝治疗不足，通过可耐受的主动脉瓣关闭不全杂音发现。治疗方法是使用尿激酶进行纤溶治疗，静脉注射剂量为4400 IU/kg/小时，持续12小时。第75天进行的临床、超声和放射性电影造影检查均正常；当时患者正在接受抗维生素K和抗血小板聚集治疗。未观察到并发症。该病例证明了纤溶治疗在瓣膜假体植入后早期血栓形成中的优势。
