Papadimitriou K, Yiagnisis M, Tolis G, Spandidos D A
Ippokration General Hospital, Athens, Greece.
Anticancer Res. 1988 Nov-Dec;8(6):1223-7.
The monoclonal antibody Y13 259 to the ras oncogene p21 product was used in an immunohistochemical study of ras expression in human thyroid neoplasms. Both papillary and follicular carcinomas showed consistently higher staining intensity than normal tissue adjacent to carcinomas. Some follicular, foetal, embryonal and oxyphil adenomas exhibited higher staining intensity than normal tissue. Our results suggest that elevated ras expression may be important in the development of some adenomas and in their conversion to carcinomas.
针对原癌基因p21产物的单克隆抗体Y13 259被用于一项关于人甲状腺肿瘤中ras表达的免疫组织化学研究。乳头状癌和滤泡状癌的染色强度始终高于癌旁正常组织。一些滤泡性腺瘤、胎儿型腺瘤、胚胎型腺瘤和嗜酸性腺瘤的染色强度高于正常组织。我们的结果表明，ras表达升高可能在一些腺瘤的发生及其向癌的转变过程中起重要作用。
