Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Nakamura S, Hashimoto T
Pathology Section, Kanazawa University Hospital, Japan.
Anticancer Res. 1995 May-Jun;15(3):755-9.
An immunohistochemical study of 24 thyroid carcinomas, 10 thyroid adenomas and 10 normal thyroids was performed using monoclonal antibodies directed against each of the three members of ras p21s; Ha-, K- and N-ras p21. Normal thyroids showed a negative staining for all of the three ras p21s. The expressional levels of the three ras p21s were various in each benign and malignant thyroid tumor, but a higher expression of Ha- and N-ras p21 and a lower or negative expression of K-ras p21 was a common finding in thyroid tumors of all histologic categories. There were no correlations between the expressional levels of ras p21s and the histologic subtypes, tumor size or lymph node status in the thyroid carcinomas.
使用针对ras p21的三个成员（Ha-ras p21、K-ras p21和N-ras p21）的单克隆抗体，对24例甲状腺癌、10例甲状腺腺瘤和10例正常甲状腺进行了免疫组织化学研究。正常甲状腺对所有三种ras p21均呈阴性染色。在每例良性和恶性甲状腺肿瘤中，三种ras p21的表达水平各不相同，但在所有组织学类型的甲状腺肿瘤中，Ha-ras p21和N-ras p21的高表达以及K-ras p21的低表达或阴性表达是常见现象。在甲状腺癌中，ras p21的表达水平与组织学亚型、肿瘤大小或淋巴结状态之间无相关性。
