[Dynamics of tissue reactions after allotransplantation of a full-thickness skin flap in mice. Immunocompetent cells in the graft bed].

A full-thickness skin graft (2.5 X 1.5 sm) is transplanted from mice C3H to mice C57B1. During 284 h after the operation the number of lymphocytes, immunoblasts, plasmoblasts, young and mature plasmocytes in the graft bed fluctuates wavely, in some cases--with certain shifts in the phase. The dynamics of these elements number, five stages are revealed: for the first stage (from 76 up to 124-136 h) a sharp increase in the number of poorly differentiated cells is specific, this is replaced, during the second stage (from 124-136 up to 156-164 h), with a relative drop in their number; during the third stage (from 156-164 up to 204 h) the number of the immune-competent cells with various degree of differentiation reincreases; during the fourth stage (from 204 up to 254 h) maximal values in the number of all the elements studied, especially those of the cell-effectors, are noted; at the fifth stage (from 254 up to 284 h) the transplanted skin graft undergoes necrotization and is rejected. Owing to the data obtained it is possible to widen and consider more objectively the quantitative criteria in evaluating the post-transplantation tissue reactions, to follow the natural periodization of the graft rejection process.