Loew F, Papavero L
Neurosurgical Clinic, Saarland University Medical School Homburg/Saar, F.R.G.
Adv Tech Stand Neurosurg. 1988;16:51-79. doi: 10.1007/978-3-7091-6954-4_2.
This review is based on literature data and own experiences in 79 patients with malignant brain tumours using intraarterial delivery of cytostatic agents as adjuvant therapy. A survey is given of the pharmacological rationale of this therapeutic approach, of the drugs which have been used and of the related experimental and clinical experiences. Advantages and limitations are discussed and clinical conclusion drawn. Experience so far suggests that in anaplastic astrocytomas and oligodendrogliomas intraarterial ACNU might be as effective as intravenous BCNU against the tumours but causes less systemic side-effects.
本综述基于文献数据以及本人对79例恶性脑肿瘤患者采用动脉内给予细胞抑制剂作为辅助治疗的经验。本文对这种治疗方法的药理学原理、所用药物以及相关的实验和临床经验进行了概述。讨论了其优点和局限性并得出临床结论。目前的经验表明，在间变性星形细胞瘤和少突胶质细胞瘤中，动脉内给予ACNU对肿瘤的疗效可能与静脉给予BCNU相当，但全身副作用较少。
