Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Department of Orthodontic, The Affiliated Dental Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Dis Markers. 2018 Dec 17;2018:9731374. doi: 10.1155/2018/9731374. eCollection 2018.
Whether serum uric acid (UA) is associated with all-cause mortality in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) remains unclear.
We performed a retrospective cohort study of 2296 patients with ACS. Curve-fitting and Cox proportional-hazard regression models with a hazard ratio (HR) and 95% confidence interval (CI) were used.
During a mean follow-up of 246.31 ± 49.16 days, 168 (7.32%) patients died from all causes. Patients were divided into two groups [the high-UA group ( = 566) and the low-UA group ( = 1730)] based on the serum UA threshold value (5.6 mg/dl) identified through curve fitting. Fifty-three (9.36%) patients died in the high-UA group, and 115 (6.65%) patients died in the low-UA group. The difference between groups was statistically significant ( = 0.031). Univariate analysis showed that the risk of all-cause mortality in the high-UA group was significantly greater than that in the low-UA group (HR = 1.45, 95% CI: 1.03 to 2.04). This difference persisted after adjustment for baseline characteristics, medical history, and medication history (HR = 1.42, 95% CI: 1.05 to 1.87).
Our study demonstrated that elevated serum UA (>5.6 mg/dl) is associated with all-cause mortality in ASC patients after PCI.
血清尿酸（UA）是否与经皮冠状动脉介入治疗（PCI）后急性冠脉综合征（ACS）患者的全因死亡率相关尚不清楚。
我们对 2296 例 ACS 患者进行了回顾性队列研究。采用曲线拟合和 Cox 比例风险回归模型，计算风险比（HR）和 95%置信区间（CI）。
在平均 246.31±49.16 天的随访期间，168 例（7.32%）患者死于各种原因。根据曲线拟合确定的血清 UA 阈值（5.6mg/dl），将患者分为两组[高 UA 组（ = 566）和低 UA 组（ = 1730）]。高 UA 组中有 53 例（9.36%）患者死亡，低 UA 组中有 115 例（6.65%）患者死亡。两组之间的差异具有统计学意义（ = 0.031）。单因素分析显示，高 UA 组的全因死亡率显著高于低 UA 组（HR=1.45，95%CI：1.032.04）。调整基线特征、病史和用药史后，这种差异仍然存在（HR=1.42，95%CI：1.051.87）。
本研究表明，PCI 后 ASC 患者血清 UA 升高（>5.6mg/dl）与全因死亡率相关。
